Small Animal Cancer Imaqina Core Small laboratory animal models such as mice, rats and hamsters are widely used throughout the cancer research community at Washington University. Indeed, with the recent revolution in molecular biology, transgenic laboratory animal models, in particular, mice have become an indispensable part of the cancer research armamentarium. Animal models of cancer, however, can present the researcher with significant challenges in deciding how best to evaluate or analyze for the characteristics or effects of interest. Most often, for example, one wishes to follow each of the individual subjects that make up a sample population over an extended time period during which various procedures are carried out. Thus, invasive and/or destructive procedures, especially those that require sacrifice of the subject, are prohibitive. Under these circumstances, nondestructive imaging modalities, such as magnetic resonance imaging, positron emission tomography, and optical imaging are especially valuable. The goals and specific aims of the Small Animal Cancer Imaging Core remain essentially as initially described, namely to bring to the Washington University and St. Louis region cancer research communities a resource that offers state-of-the-art small animal magnetic resonance imaging, positron emission tomography, and optical imaging. As described in this document, optical imaging is being added as a new modality to the Core. The attributes of optical imaging complement those of positron emission tomography and magnetic resonance imaging. In particular, optical imaging offers extremely high signal detection sensitivity with target-specific (molecular) labeling while avoiding the difficulties inherent with radionuciides. Optical Imaging faces challenges in probing deep lying structures, a strength of PET, and in achieving high spatial resolution, a strength of MRI. Thus, the three modalities are complementary, rather than redundant, and offer great opportunities for multi-modal assessment of small animal cancer models.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA091842-07
Application #
7497935
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
7
Fiscal Year
2007
Total Cost
$309,335
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Waqar, Saiama N; Waqar, Sadaf H; Trinkaus, Kathryn et al. (2018) Brain Metastases at Presentation in Patients With Non-Small Cell Lung Cancer. Am J Clin Oncol 41:36-40
May-Zhang, Aaron A; Deal, Karen K; Southard-Smith, E Michelle (2018) Optimization of Laser-Capture Microdissection for the Isolation of Enteric Ganglia from Fresh-Frozen Human Tissue. J Vis Exp :
Harris-Hayes, Marcie; Steger-May, Karen; van Dillen, Linda R et al. (2018) Reduced Hip Adduction Is Associated With Improved Function After Movement-Pattern Training in Young People With Chronic Hip Joint Pain. J Orthop Sports Phys Ther 48:316-324
Beleckas, Casey M; Gerull, William; Wright, Melissa et al. (2018) Variability of PROMIS Scores Across Hand Conditions. J Hand Surg Am :
Prudner, Bethany Cheree; Sun, Fangdi; Kremer, Jeffrey Charles et al. (2018) Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas. Theranostics 8:2107-2116
Mundt, Filip; Rajput, Sandeep; Li, Shunqiang et al. (2018) Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers. Cancer Res 78:2732-2746
Burclaff, Joseph; Mills, Jason C (2018) Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas. Dis Model Mech 11:
Meinerz, Kelsey; Beeman, Scott C; Duan, Chong et al. (2018) Bayesian Modeling of NMR Data: Quantifying Longitudinal Relaxation in Vivo, and in Vitro with a Tissue-Water-Relaxation Mimic (Crosslinked Bovine Serum Albumin). Appl Magn Reson 49:3-24
Rocha, Agostinho G; Franco, Antonietta; Krezel, Andrzej M et al. (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360:336-341
Lin, Jonathan B; Sene, Abdoulaye; Santeford, Andrea et al. (2018) Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging. EBioMedicine 32:9-20

Showing the most recent 10 out of 1244 publications