The Breast Cancer Research Program includes 29 faculty members from eight departments and two schools to form an integrated program that is dedicated to research on the prevention, diagnosis and treatment of breast cancer. The program is currently supported by $3,465,104 in NCI funding and $4,755,188 in other peer-reviewed funding. Program members have diverse interests including research into breast health communications, the pathology and biology of premalignant lesions, the development of intrinsic breast cancer subtype assays, translational research on endocrine therapy resistance in the context of cooperative group neoadjuvant endocrine therapy trials, the development of novel therapeutics that target both tumor cells and bone and the immune system cells. We are also very actively investigating novel imaging approaches for predicting response to hormonal therapy. In addition, the program is now collaborating with the Washington University Genome Sequencing Center in an effort to unravel the genetic changes associated with breast susceptibility, initiation, progression, relapse, and resistance. Program members are developing new breast cancer models in order to develop preclinical justifications for investigator initiated clinical trials in our developmental therapeutics programs. Classes of agent under development include phosphoinositol-3-kinase inhibitors, hedgehog inhibitors, check point homolog kinase (CHK1) inhibitors and Trop2 antibodies. The program consists of a number of basic, translational, and clinical investigators who meet weekly in a highly interactive scientific milieu. Large numbers of breast cancer patients are being treated on clinical protocols at Washington University with a number of Siteman Cancer Center cores are essential for the mission ofthe program, including the Clinical Trials Core, Imaging Response Assessment Team, Tissue Procurement Core, the Molecular and Genomic Analysis Core, the Biostatistics Core, the Bioinformatics Core, and the Proteomics Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA091842-11
Application #
8380300
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
11
Fiscal Year
2012
Total Cost
$62,815
Indirect Cost
$55,503
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Salloum, Naji C; Buchalter, Erica Lf; Chanani, Swati et al. (2018) From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation. Pharmacogenomics 19:861-871
Aliev, Fazil; Salvatore, Jessica E; Agrawal, Arpana et al. (2018) A Brief Critique of the TATES Procedure. Behav Genet 48:155-167
Mills, Jason C; Samuelson, Linda C (2018) Past Questions and Current Understanding About Gastric Cancer. Gastroenterology 155:939-944
Shepherd, Andrew J; Copits, Bryan A; Mickle, Aaron D et al. (2018) Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain. J Neurosci 38:7032-7057
Dehdashti, Farrokh; Wu, Ningying; Bose, Ron et al. (2018) Evaluation of [89Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer. Breast Cancer Res Treat 169:523-530
Donabedian, Patrick L; Kossatz, Susanne; Engelbach, John A et al. (2018) Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models. EJNMMI Res 8:59
Groves, Andrew P; Gettinger, Katie; Druley, Todd E et al. (2018) Special Therapy and Psychosocial Needs Identified in a Multidisciplinary Cancer Predisposition Syndrome Clinic. J Pediatr Hematol Oncol :
Andley, Usha P; Tycksen, Eric; McGlasson-Naumann, Brittney N et al. (2018) Probing the changes in gene expression due to ?-crystallin mutations in mouse models of hereditary human cataract. PLoS One 13:e0190817
Sáenz, José B; Mills, Jason C (2018) Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer. Nat Rev Gastroenterol Hepatol 15:257-273
Miller, Christopher A; Tricarico, Christopher; Skidmore, Zachary L et al. (2018) A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion. Blood Adv 2:1295-1299

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