The Embryonic Stem Cell (ESC) Core is responsible for: ? Creating and providing state-of-the-art reagents for the production of targeted mutations in murine embryonic stem cells. ? Creating and maintaining quality-controlled embryonic stem cell lines from a variety of mouse backgrounds. ? Teaching the methodology of embryonic stem cell culture and manipulation. The ESC Core provides consultative services for Siteman Cancer Center members when they are designing knock-out or knock-in vectors, and it creates and distributes user-friendly plasmids that facilitate the generation of targeting vectors. By providing a comprehensive service, the ESC Core facilitates the production of gain-offunction and loss-of-function mouse models for Siteman Cancer Center faculty.
This core assists investigators in the Cancer Center with the generation of reagents used to make sophisticated mouse models of human diseases, including cancer. These reagents help us to understand how individual genes work, and how mutations work to cause cancer.
| Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214 |
| Song, Wilbur M; Joshita, Satoru; Zhou, Yingyue et al. (2018) Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760 |
| Gauvain, Karen; Ponisio, Maria Rosana; Barone, Amy et al. (2018) 18F-FDOPA PET/MRI for monitoring early response to bevacizumab in children with recurrent brain tumors. Neurooncol Pract 5:28-36 |
| Yang, Ruimeng; Duan, Chong; Yuan, Liya et al. (2018) Inhibitors of HIF-1? and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain. Int J Radiat Oncol Biol Phys 100:1016-1025 |
| Willet, Spencer G; Lewis, Mark A; Miao, Zhi-Feng et al. (2018) Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J 37: |
| Staples, Robert; London, Daniel A; Dardas, Agnes Z et al. (2018) Comparative Morbidity of Cubital Tunnel Surgeries: A Prospective Cohort Study. J Hand Surg Am 43:207-213 |
| Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530 |
| Waqar, Saiama N; Boehmer, Leigh; Morgensztern, Daniel et al. (2018) Immunogenicity of Influenza Vaccination in Patients With Cancer. Am J Clin Oncol 41:248-253 |
| Duncavage, Eric J; Jacoby, Meagan A; Chang, Gue Su et al. (2018) Mutation Clearance after Transplantation for Myelodysplastic Syndrome. N Engl J Med 379:1028-1041 |
| Eberth, Jan M; Josey, Michele J; Mobley, Lee R et al. (2018) Who Performs Colonoscopy? Workforce Trends Over Space and Time. J Rural Health 34:138-147 |
Showing the most recent 10 out of 1244 publications
