Many researchers are interested in utilizing state-of-the-art technologies such as microarray-basedtranscriptomic and genomic analyses to attempt to dissect molecular profiles. Within the past decade wehave witnessed significant advancements in research that are directly associated with the output of thegenome sequencing endeavor. The results of these achievements provide hope to investigators researchingcomplex diseases like cancer. Alterations in genes causing these diseases may result in one or severalgenes having aberrant genomic profiles or even hundreds to thousands of genes with perturbed function.This can result in a mishmash of genomic profiles that is difficult to sort through, presenting a challenge toresearchers attempting to elucidate the cause and effect of cancer.To assist BCMCC investigators with these issues, the Genomic Profiling Resource will integrate two existingBaylor College of Medicine (BCM) facilities to provide state-of-the-art access to transcriptional or genomicprofiling using microarray technology. The Resource utilizes spotted glass microarrays and the commerciallyavailable Affymetrix GeneChip platform and offers expert advice in experimental design, data analysis, andbioinformatics, as well as access to computing hardware and software. Services offered by the Resourceinclude sample quality control, expression profiling with microarrays, quantitative (real time) PCR, access toa cDNA clone respository, comparative genomic hybridization on spotted arrays, SNP genotyping utilizingAffymetrix GeneChips, data analysis, training, and workshops. Led by Drs. Lisa White and Ching Lau, thisCore will provide a cost-effective resource for Cancer Center researchers.
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