The Biostatistics Resource is a new resource that arose from existing successful programs in the Biostatistics, Informatics, and Data Management Section of the Breast Center, and in the Bioinformatics Resource of the Prostate SPORE. This BCMCC Resource currently comprises three PhD faculty, one MS faculty, and three MS staff biostatisticians. The Resource is already well-integrated into the Cancer Center, providing support to investigators in every Program during the last year and coauthoring 22 peer-reviewed publications with Cancer Center investigators. More than 70% of the current personnel budget for the Resource was covered by charge-backs on peer-reviewed funding. The Biostatistics Resource is led by Susan G. Hilsenbeck, Ph.D., who has extensive experience in organizing and providing biostatistical and data management support for both cancer clinical trials and basic research studies. The primary purpose of the Resource is to support the research efforts of the Cancer Center through collaboration on biostatistical aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical assistance including general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development, and interpretation;education and training;statistical review for PRMS;and consultation on database development. In order to truly fulfill this purpose, the Resource will have to expand. We will first recruit additional faculty with expertise in clinical trials in order to meet the pressing and immediate need in this area. Subsequent recruits will address unmet needs in more basic and genomic studies. We are also reaching out to other quantitative scientists within the College who have special expertise that may benefit Cancer Center investigators. In this way the Resource will provide Cancer Center investigators with strong, broad-based biostatistical expertise.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA125123-03
Application #
7900432
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$190,532
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Reznik, Ed; Luna, Augustin; Aksoy, Bülent Arman et al. (2018) A Landscape of Metabolic Variation across Tumor Types. Cell Syst 6:301-313.e3
Blue, R Eric; Koushik, Amrita; Engels, Nichlas M et al. (2018) Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. Int J Biochem Cell Biol 105:134-143
Dawson, Emily P; Lanza, Denise G; Webster, Nicholas J et al. (2018) Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency. Development 145:
Zhao, Na; Cao, Jin; Xu, Longyong et al. (2018) Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299
Parikh, Neha; Shuck, Ryan L; Gagea, Mihai et al. (2018) Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice. Aging Cell 17:
Brunetti, Lorenzo; Gundry, Michael C; Kitano, Ayumi et al. (2018) Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. J Vis Exp :
Newton, Jared M; Flores-Arredondo, Jose H; Suki, Sarah et al. (2018) Non-Invasive Radiofrequency Field Treatment of 4T1 Breast Tumors Induces T-cell Dependent Inflammatory Response. Sci Rep 8:3474
Freire, Pablo R; Conneely, Orla M (2018) NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBP? and inflammatory signaling. Blood 131:1081-1093
Lyon, Deborah; Lapteva, Natasha; Gee, Adrian P (2018) Absence of Replication-Competent Retrovirus in Vectors, T Cell Products, and Patient Follow-Up Samples. Mol Ther 26:6-7
Yosef, Nejla; Vadakkan, Tegy J; Park, June-Hee et al. (2018) The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages. Dev Biol 442:138-154

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