Harold C. Simmons Cancer Center Population Science and Cancer Control Scientific Program Project Summary/Abstract A developing research program in the 2009 application, the Population Science and Cancer Control (PS) Scientific Program has grown substantially in peer-reviewed funding from less than $500,000 to $5.6 million in 2013. Of that amount, $2.5 million represents funding from the NCI, $1.5 million from other NIH divisions, and close to $1 million from the Agency for Healthcare Research and Quality (AHRQ). Total prevention and screening projects from the Cancer Prevention and Research Institute of Texas (CPRIT) currently totals $2.4 million. Intra-programmatic collaborations are strong, representing 44% of the Program's 2013 publications; 13% are inter-programmatic. Program members meet quarterly for updates and research presentations, with topic- focused bi-monthly works-in-progress sessions. Our large catchment area is the Dallas-Ft. Worth statistical metropolitan area, with a special focus on uninsured Dallas county residents cared for by the Parkland Health and Hospital System . Thus, the program has a heavy focus on cancer disparities and conducts research among large numbers of traditionally underserved individuals. To address the needs of this catchment area, the PS Program functions along the following themes: Theme 1: Cancer prevention research includes study of biomarkers and behaviors 1.a. Biomarkers for colon and hepatocellular cancers 1.b. Risk prevention behaviors Theme 2: Screening for early detection of colon, hepatocellular, and esophageal cancers 2.a. Population-based screening for colon cancer 2.b. Screening for hepatocellular cancer 2.c. Screening for esophageal cancer Theme 3: Survivorship (Developing) We have focused on programmatic grants allowing for discoveries across processes of care that can be translated into improved care in our catchments' health systems. Sixteen of 24 members have been recruited to Dallas since the arrival of Co-Leader Dr. Celette Sugg Skinner in 2007: six PhDs in the Department of Clinical Sciences with strong and diverse skills in mixed-methods, geo-spatial, biomedical, and multi-level research; a psychologist in the Department of Psychiatry; five MDs in the Department of Medicine with expertise in clinical epidemiology and health services research; and four PhDs in cancer-related health promotion and epidemiology in the UT School of Public Health's Dallas Campus.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA142543-09
Application #
9537588
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
9
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
LaRanger, Ryan; Peters-Hall, Jennifer R; Coquelin, Melissa et al. (2018) Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells. Tissue Eng Part A 24:559-568
Knudsen, Erik S; Balaji, Uthra; Mannakee, Brian et al. (2018) Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility. Gut 67:508-520
Kim, Wanil; Shay, Jerry W (2018) Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD). Differentiation 99:1-9
Li, Shulong; Yang, Ning; Li, Bin et al. (2018) A pilot study using kernelled support tensor machine for distant failure prediction in lung SBRT. Med Image Anal 50:106-116
Wang, Shidan; Chen, Alyssa; Yang, Lin et al. (2018) Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome. Sci Rep 8:10393
An, Weiwei; Mason, Ralph P; Lippert, Alexander R (2018) Energy transfer chemiluminescence for ratiometric pH imaging. Org Biomol Chem 16:4176-4182
O'Kelly, Devin; Zhou, Heling; Mason, Ralph P (2018) Tomographic breathing detection: a method to noninvasively assess in situ respiratory dynamics. J Biomed Opt 23:1-6
Chen, Yan; Zhang, Bo; Bao, Lei et al. (2018) ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis. J Clin Invest 128:1937-1955
Stallings, Nancy R; O'Neal, Melissa A; Hu, Jie et al. (2018) Pin1 mediates A?42-induced dendritic spine loss. Sci Signal 11:
Sudhan, Dhivya R; Schwarz, Luis J; Guerrero-Zotano, Angel et al. (2018) Extended Adjuvant Therapy with Neratinib Plus Fulvestrant Blocks ER/HER2 Crosstalk and Maintains Complete Responses of ER+/HER2+ Breast Cancers: Implications to the ExteNET Trial. Clin Cancer Res :

Showing the most recent 10 out of 501 publications