Abstract

? MICROSCOPY SHARED RESOURCE Shared Resource Leader: Victor Friedrich, PhD The Tisch Cancer Institute (TCI) Microscopy Shared Resource Facility (MSRF) provides equipment, training, and expert consultation services for a full range of light microscopy applications, including confocal and multiphoton microscopes, four epi-fluorescence/brightfield systems, including structured illumination attachments, and software and workstations for deconvolution and other image processing, as well as image analysis. Two full time, masters-level engineers are present in the facility during regular hours to provide real time assistance to novice users. The high z-resolution and multichannel capabilities of the microscope systems are crucial for cancer studies involving immunofluorescence and fluorescent protein applications (e.g. localization of cell signaling and growth regulatory molecules, cell migration, and the effects of genetic and pharmacological manipulations on differentiation). The MSRF is comprised of the institutional Microscopy Shared Resource Facility and two TCI satellite sites that have been set up to better serve members of the Tisch Cancer Institute.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA196521-05
Application #
9754079
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

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Abbate, Franco; Badal, Brateil; Mendelson, Karen et al. (2018) FBXW7 regulates a mitochondrial transcription program by modulating MITF. Pigment Cell Melanoma Res :
Linde, Nina; Casanova-Acebes, Maria; Sosa, Maria Soledad et al. (2018) Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun 9:21
Sonoshita, Masahiro; Scopton, Alex P; Ung, Peter M U et al. (2018) A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol 14:291-298
Hirschfield, Hadassa; Bian, C Billie; Higashi, Takaaki et al. (2018) In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment. Exp Mol Med 50:e419
Rattay, T; Symonds, R P; Shokuhi, S et al. (2018) The Patient Perspective on Radiogenomics Testing for Breast Radiation Toxicity. Clin Oncol (R Coll Radiol) 30:151-157

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