The aim of this Center is to provide scientific resources for studying the nutritional, endocrine, and metabolic aspects of HIV infection in chronic drug users of different ethnicities (Caucasian, Hispanic, and African-Americans) who are using various types of illicit drugs. HIV-positive drug users face a unique set of issues and challenges that may exacerbate their illness, including poor nutrition, inadequate medical care, difficulties adhering to complicated therapeutic regimens, and the use of specific drugs known to impair metabolic function. Investigation of the overall nutrition, endocrine, and metabolic effects of HIV infection in the general HIV-positive population, however, seldom extends to the drug using population, a group in which 50% of new HIV infections occurs. This Center will consist of 6 Cores: Administrative, Developmental, Drug User Resources, Nutrition and Metabolism, Endocrine, and Epidemiology/Biostatistics. The Center will build upon an existing infrastructure of studies in drug users at four East Coast institutions (Tufts University School of Medicine in Boston, Massachusetts; Brown University School of Medicine in Providence, Rhode Island; Johns Hopkins Medical Institutions in Baltimore, Maryland; and the New York Academy of Medicine, in New York City, New York). Tufts has developed programs in specific nutrition and metabolic aspects of HIV infection and has a research program in Hispanic drug users with and without HIV. Brown University has developed expertise in conducting research among specialized populations, including injection drug users, substance abusing women, and incarcerated drug users. Johns Hopkins has research in endocrine disorders among drug users with HIV, and has active longitudinal studies of African-American injection drug users. The New York Academy of Medicine's Center for Urban Epidemiologic Studies has several ongoing research studies related to HIV infection in drug using populations. The proposed Center will combine the complementary resources and expertise that exist at each of the collaborating sites to develop a new research program that will focus on the nutritional, metabolic, and endocrine abnormalities in HIV-positive and HIV-negative drug users.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
1P30DA013868-01A1
Application #
6450580
Study Section
Special Emphasis Panel (ZDA1-RXL-E (14))
Program Officer
Khalsa, Jagjitsingh H
Project Start
2002-09-25
Project End
2007-06-30
Budget Start
2002-09-25
Budget End
2003-06-30
Support Year
1
Fiscal Year
2002
Total Cost
$999,262
Indirect Cost
Name
Tufts University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Kohli, Rakhi; Winston, Diana; Sheehan, Heidi et al. (2016) Cholesterol Levels in HIV- and/or HCV-Infected Drug Users Living in Argentina. J Int Assoc Provid AIDS Care 15:400-5
Slama, Laurence; Jacobson, Lisa P; Li, Xiuhong et al. (2016) Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men. J Acquir Immune Defic Syndr 71:57-64
Dinh, Duy M; Volpe, Gretchen E; Duffalo, Chad et al. (2015) Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis 211:19-27
Kapulsky, Leonid; Tang, Alice M; Forrester, Janet E (2015) Food insecurity, depression, and social support in HIV-infected Hispanic individuals. J Immigr Minor Health 17:408-13
Tang, Alice M; Quick, Timothy; Chung, Mei et al. (2015) Authors' Reply: Nutritional Support to HIV Patients Starting ART. J Acquir Immune Defic Syndr 70:e69-70
Hong, Steven Y; Fanelli, Theresa J; Jonas, Anna et al. (2014) Household food insecurity associated with antiretroviral therapy adherence among HIV-infected patients in Windhoek, Namibia. J Acquir Immune Defic Syndr 67:e115-22
Lambert, Allison A; Drummond, M Bradley; Mehta, Shruti H et al. (2014) Risk factors for vitamin D deficiency among HIV-infected and uninfected injection drug users. PLoS One 9:e95802
Lambert, Allison A; Kirk, Gregory D; Astemborski, Jacquie et al. (2014) A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort. PLoS One 9:e95099
Jordan, M R; Obeng-Aduasare, Y; Sheehan, H et al. (2014) Correlates of non-adherence to antiretroviral therapy in a cohort of HIV-positive drug users receiving antiretroviral therapy in Hanoi, Vietnam. Int J STD AIDS 25:662-668
Dugdale, Caitlin; Zaller, Nickolas; Bratberg, Jeffrey et al. (2014) Missed opportunities for HIV screening in pharmacies and retail clinics. J Manag Care Spec Pharm 20:339-45

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