The objectives of the Biological Data Acquisition and Analysis Core are the following: 1) to enhance the biological resources of existing Center studies and pilot studies; 2) to maximize their productivity with existing biological resources; 3) to inform, educate and train Center investigators, affiliates, postdoctoral fellows, and students on novel and innovative biological methods; and 4) to promote collaborative science across Center projects. The core staff will provide individualized consultation with Center projects to evaluate resources and opportunities, develop a plan to enhance resources and initiate collaboration, provide project management support to ensure smooth coordination with facilities and timely completion, supplement project resources to assist with data analysis and writing, and provide access to training/educative opportunities to investigators and staff. The team will be co-led by Dr. Timothy Strauman, who has expertise in the use of brain imaging techniques to study mechanisms relevant for self-regulation, and Dr. Cynthia Kuhn, a pharmacologist, whose laboratory will provide a core facility for studies looking to assay stress and immune-related biomarkers. Their team will be joined by a set of partner facilities/resources in genomics/epigenetics, neuroimaging, biomarker assessment, electronic health records, bioinformatics and biobanking. Matching these resources with Center projects will stimulate novel insights into the interplay between early experiences, regulatory processes, underlying biological systems, and behavioral outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
5P30DA023026-12
Application #
9968206
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
12
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Odgers, Candice (2018) Smartphones are bad for some teens, not all. Nature 554:432-434
Anderson, Sarah L; Zheng, Yao; McMahon, Robert J (2018) Do Callous-Unemotional Traits and Conduct Disorder Symptoms Predict the Onset and Development of Adolescent Substance Use? Child Psychiatry Hum Dev 49:688-698
Hanson, Jamie L; Knodt, Annchen R; Brigidi, Bartholomew D et al. (2018) Heightened connectivity between the ventral striatum and medial prefrontal cortex as a biomarker for stress-related psychopathology: understanding interactive effects of early and more recent stress. Psychol Med 48:1835-1843
King, Kevin M; Luk, Jeremy W; Witkiewitz, Katie et al. (2018) Externalizing Behavior Across Childhood as Reported by Parents and Teachers: A Partial Measurement Invariance Model. Assessment 25:744-758
Zheng, Yao; Albert, Dustin; McMahon, Robert J et al. (2018) Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. Prev Sci 19:79-89
Zheng, Yao; Pasalich, Dave S; Oberth, Carla et al. (2017) Capturing Parenting as a Multidimensional and Dynamic Construct with a Person-Oriented Approach. Prev Sci 18:281-291
Golonka, Megan M; Peairs, Kristen F; Malone, Patrick S et al. (2017) Natural Peer Leaders as Substance Use Prevention Agents: the Teens' Life Choice Project. Prev Sci 18:555-566
Strauman, Timothy J; Eddington, Kari M (2017) Treatment of Depression From a Self-Regulation Perspective: Basic Concepts and Applied Strategies in Self-System Therapy. Cognit Ther Res 41:1-15
Hill, Sherika; Shanahan, Lilly; Costello, E Jane et al. (2017) Predicting Persistent, Limited, and Delayed Problematic Cannabis Use in Early Adulthood: Findings From a Longitudinal Study. J Am Acad Child Adolesc Psychiatry 56:966-974.e4
Swartz, Johnna R; Prather, Aric A; Di Iorio, Christina R et al. (2017) A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men. Neuropsychopharmacology 42:419-426

Showing the most recent 10 out of 127 publications