This is the University of Washington application for a Research Core Grant from the NIDCD. The NIDCD funded Research base is composed of 19 grants to 16 investigators supported by $33,515,491 annual direct costs. The Cores will also provide infrastructure support for 5 NIH funded investigators whose research is in research programs, and to stimulate new research initiatives. The Human Subject Recruitment Core will continue a long-standing infant subject pool that is essential for research on the development of hearing and language perception in human infants and babies. Also, databases will be developed on populations of subjects with specific hearing and perceptual impairments. The Computer Resources Core will provide personnel with skills needed for development of software for real-time physiological and behavioral investigations of auditory processing in animals and humans. In addition,, a system and network manager is to be hired to teach and advice investigators on the optimal computer solutions. The Imaging Core will provide personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal Microscopy, 3-dimensional reconstructions and quantitative analyses of cellular attributes. The Core will also support human brain imaging initiatives. The Mouse Genetics Core will control breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment will be provided for rapid analyses of DNA sequences to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores will be supported by an Administrative Core to oversee the operations of each Research Core, organize group meetings, provide clerical, fiscal and personnel support, and prepare reports to funding agency.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
1P30DC004661-01
Application #
6216317
Study Section
Special Emphasis Panel (ZDC1-SRB-J (15))
Program Officer
Donahue, Amy
Project Start
2000-09-25
Project End
2005-08-31
Budget Start
2000-09-25
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$691,901
Indirect Cost
Name
University of Washington
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Stone, Jennifer S; Wisner, Serena R; Bucks, Stephanie A et al. (2018) Characterization of Adult Vestibular Organs in 11 CreER Mouse Lines. J Assoc Res Otolaryngol 19:381-399
Daliri, Ayoub; Max, Ludo (2018) Stuttering adults' lack of pre-speech auditory modulation normalizes when speaking with delayed auditory feedback. Cortex 99:55-68
Lewis, Rebecca M; Keller, Jesse J; Wan, Liangcai et al. (2018) Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium. Hear Res 364:1-11
Maruthy, Santosh; Feng, Yongqiang; Max, Ludo (2018) Spectral Coefficient Analyses of Word-Initial Stop Consonant Productions Suggest Similar Anticipatory Coarticulation for Stuttering and Nonstuttering Adults. Lang Speech 61:31-42
Lau, Bonnie K; Lalonde, Kaylah; Oster, Monika-Maria et al. (2017) Infant pitch perception: Missing fundamental melody discrimination. J Acoust Soc Am 141:65
Minich, Rebecca R; Li, Jin; Tempel, Bruce L (2017) Early growth response protein 1 regulates promoter activity of ?-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system. BMC Mol Biol 18:14
Warchol, Mark E; Stone, Jennifer; Barton, Matthew et al. (2017) ADAM10 and ?-secretase regulate sensory regeneration in the avian vestibular organs. Dev Biol 428:39-51
Cabrera, Laurianne; Werner, Lynne (2017) Infants' and Adults' Use of Temporal Cues in Consonant Discrimination. Ear Hear 38:497-506
Wu, Yu-Hsiang; Dumanch, Kelsey; Stangl, Elizabeth et al. (2017) Is the Device-Oriented Subjective Outcome (DOSO) Independent of Personality? J Am Acad Audiol 28:932-940
Bucks, Stephanie A; Cox, Brandon C; Vlosich, Brittany A et al. (2017) Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice. Elife 6:

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