Investigators at the Mount Sinai School of Medicine and BrooklynCollege of the City University of New York (CUNY) holding research grants fromthe NIDCD and with NIH projects in the area of the Program Goals of the NIDCDare applying to renew the grant that supports the Core Center over the last fiveyears. One thread through several of the research projects is to determine thecharacteristics and neural bases of spatial orientation and locomotion. Otherresearch is devoted to defining vestibular control of the autonomic system, thecellular and molecular basis of vestibular adaptation, and the molecular biology .ofvestibular development. A second thread is to develop a better understanding ofearly immediate gene changes associated with adaptation to vestibular stimulation.A third thread is to develop models of neural function that can be used to providenew pathways to study disease. An important aspect of the collaboration is fortranslational research on Parkinson locomotion, autonomic function, and motionsickness. There has been considerable interaction among members of the groupdue to the support provided by the CORE. There have also been advances due tothe high level of services and technical support and development that have fosteredbetter research in every area. Theodore Raphan will direct a Computer,Networking, and Electronic Module; Sergei Yakushin, Ph.D. will direct anEngineering and Mechanical Maintenance Module. Bernard Cohen and TheodoreRaphan will serve as Core Director and Associate Director, respectively. The goalof the proposed Core Center is to promote the research of each group by providingessential services, technical advances, and new methodologies that are tooexpensive or complex for any one group to carry or develop individually. Asecond goal is to provide an intellectual nexus through the Core Center that willhelp unite the group and promote interactions among research teams. The third isto establish translational research that will benefit patients with problems inlocomotion, motion sickness, and autonomic function. Through the last objective,we anticipate that the perspectives of the various groups will be broadened and thatthe Core Center will foster interdisciplinary studies that will enhance achievementof our common research goals.
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