The Core Center Grant for Balance Research at the University of Pittsburgh consists of two Cores, an Animal Vestibular Neurophysiology Core (AVNC) and a Human Virtual Reality Core (HVRC). These Cores will serve both basic scientists and clinical investigators who perform research related to balance function using animal models, normal human subjects, and patients with balance disorders. The overall goal of the two research cores for which support is requested is to foster collaborative research activities in an efficient and cost-effective manner among a group of independently-funded investigators, each of whom studies some aspect of balance function or dysfunction. The Animal Vestibular Neurophysiology Core (AVNC) will consist of two separate facilities capable of delivering precise, computer-controlled, vestibular stimulation to awake behaving mammals including subhuman primates. These facilities are fully equipped for producing natural vestibular stimuli and recording various responses, including the firing of isolated single neurons. The AVNC facility will support the synergistic and collaborative research activities of several existing laboratories whose equipment is currently in heavy use. This Core will allow additional new experiments that go beyond the capabilities of the existing individual laboratories. The HVRC will consist of a projection-based immersive environment that allows control of the entire visual field, including the floor, of upright research subjects. Objective subject monitoring capabilities include video oculography-based binocular eye position, six degree-of-freedom head movement monitoring, motion analysis, ground reaction forces measured by a force plate, heart rate, and blood pressure. This Core will be used extensively to assess the influence of visual stimuli on upright balance in normal human subjects and patients with balance disorders. The facility will foster collaborative interactions among investigators with various backgrounds including bioengineering, biomechanics, physical therapy, neurology, and psychiatry. The two proposed research Cores will occupy 1110 square feet in the Otolaryngology Research Center on the first floor of the Eye and Ear Institute. The Core Grant Director, Associate Director, and Research Core Directors will provide management of the resources in the Cores to assure appropriate data quality and resource allocation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005205-03
Application #
6649770
Study Section
Special Emphasis Panel (ZDC1-SRB-J (12))
Program Officer
Platt, Christopher
Project Start
2001-09-24
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$362,446
Indirect Cost
Name
University of Pittsburgh
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Alsalaheen, Bara A; Whitney, Susan L; Marchetti, Gregory F et al. (2016) Relationship Between Cognitive Assessment and Balance Measures in Adolescents Referred for Vestibular Physical Therapy After Concussion. Clin J Sport Med 26:46-52
Fuhrman, Susan I; Redfern, Mark S; Jennings, J Richard et al. (2015) Interference between postural control and spatial vs. non-spatial auditory reaction time tasks in older adults. J Vestib Res 25:47-55
Alahmari, Khalid A; Sparto, Patrick J; Marchetti, Gregory F et al. (2014) Comparison of virtual reality based therapy with customized vestibular physical therapy for the treatment of vestibular disorders. IEEE Trans Neural Syst Rehabil Eng 22:389-99
Sparto, Patrick J; Jennings, J Richard; Furman, Joseph M et al. (2014) Lateral step initiation behavior in older adults. Gait Posture 39:799-803
Sparto, Patrick J; Fuhrman, Susan I; Redfern, Mark S et al. (2014) Postural adjustment errors during lateral step initiation in older and younger adults. Exp Brain Res 232:3977-89
Karim, Helmet T; Sparto, Patrick J; Aizenstein, Howard J et al. (2014) Functional MR imaging of a simulated balance task. Brain Res 1555:20-7
Mohammad, Maha T; Furman, Joseph M; Sparto, Patrick J et al. (2013) The effect of optotype size and velocity parameters on the performance of healthy young adult subjects on the gaze stabilization test. Otol Neurotol 34:1090-5
Whitney, Susan L; Sparto, Patrick J; Cook, James R et al. (2013) Symptoms elicited in persons with vestibular dysfunction while performing gaze movements in optic flow environments. J Vestib Res 23:51-60
Sparto, Patrick J; Fuhrman, Susan I; Redfern, Mark S et al. (2013) Postural adjustment errors reveal deficits in inhibition during lateral step initiation in older adults. J Neurophysiol 109:415-28
Suzuki, Takeshi; Sugiyama, Yoichiro; Yates, Bill J (2012) Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes. Am J Physiol Regul Integr Comp Physiol 302:R965-75

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