The goal of this Core is to provide faculty in the Center for Hearing and Balance, and associatedlaboratories, with access to histological equipment and expertise and assistance. The visualization andquantification of structural features that correlate with physiological, developmental, and/or plasticphenomena within the peripheral and central nervous systems provide fundamental data necessary to inferbasic mechanisms of neural function. But with the increasingly specialized nature of science, the expenseand difficulty of such studies can place them out of reach for most laboratories. Common resources fostercollaborations between scientists with different skill sets and can be the key to implementing excitingresearch projects that bridge different levels of analysis. Anatomical data frequently support this bridge.The Histology Core will continue to provide assistance as well as access to, and instruction in the tools andresources required for tissue preparation and sectioning for light microscopy. This includes both plasticembeddedand frozen sections. The Core provides and maintains a light/fluorescence compoundmicroscope with digital camera for image acquisition and auxiliary workstations for analysis. In addition theCore will enable ultrastructural studies through the services of an experienced electron microsopist.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005211-07
Application #
7671253
Study Section
Special Emphasis Panel (ZDC1)
Project Start
2008-09-01
Project End
2012-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
7
Fiscal Year
2008
Total Cost
$281,406
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lauer, Amanda M; Larkin, Gail; Jones, Aikeen et al. (2018) Behavioral Animal Model of the Emotional Response to Tinnitus and Hearing Loss. J Assoc Res Otolaryngol 19:67-81
Wu, Jingjing Sherry; Vyas, Pankhuri; Glowatzki, Elisabeth et al. (2018) Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrp?) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea. J Comp Neurol 526:425-438
Jones, Aikeen; May, Bradford J (2018) Effects of Acoustic Environment on Tinnitus Behavior in Sound-Exposed Rats. J Assoc Res Otolaryngol 19:133-146
Zachary, Stephen; Nowak, Nathaniel; Vyas, Pankhuri et al. (2018) Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea. J Neurosci 38:5677-5687
Moglie, Marcelo J; Fuchs, Paul A; Elgoyhen, Ana Belén et al. (2018) Compartmentalization of antagonistic Ca2+ signals in developing cochlear hair cells. Proc Natl Acad Sci U S A 115:E2095-E2104
Cunningham, Christopher L; Wu, Zizhen; Jafari, Aria et al. (2017) The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. Elife 6:
Lauer, Amanda M (2017) Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice. Front Neurosci 11:304
Johnson, Luke A; Della Santina, Charles C; Wang, Xiaoqin (2017) Representations of Time-Varying Cochlear Implant Stimulation in Auditory Cortex of Awake Marmosets (Callithrix jacchus). J Neurosci 37:7008-7022
Jones, Aikeen; May, Bradford J (2017) Improving the Reliability of Tinnitus Screening in Laboratory Animals. J Assoc Res Otolaryngol 18:183-195
Vyas, Pankhuri; Wu, Jingjing Sherry; Zimmerman, Amanda et al. (2017) Tyrosine Hydroxylase Expression in Type II Cochlear Afferents in Mice. J Assoc Res Otolaryngol 18:139-151

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