The oral mucosa lining the oral cavity represents a barrier that limits the access of exogenous material to the underlying tissues. Measurements of permeability of the tissue in man and experimental animals indicates that there is considerable variation between different oral regions. Such variation might explain the susceptibility of certain oral regions to disease, where an extrinsic etiology, such as tobacco or alcohol, is involved. A question that arises is whether common pathological conditions of the mucosa such as hyperplasia and hyperkeratosis, which are known to represent a higher risk of malignant disease than unaltered mucosa, are areas of high permeability. The hypotheses underlying the research is that any agent coming in contact with the surface of the oral mucosa must first penetrate the permeability barrier of the epithelium before it can exert a local effect.
The specific aim i s to determine whether the permeability of human oral mucosa is modified in areas of epithelial alteration, such a hyperplasia and hyperkeratosis. The research will involve the use of methods to measure permeability using specific radiolabeled tracers. Procedures will be modified to permit the use of small (4 mm diameter) biopsies of human oral mucosa. The outcomes will provide important information on the etiology of mucosal disease and will permit investigation of conditions in which increased permeability may be an important etiologic factor.
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| Watkins, Catherine; Ettinger, Ronald L; Cowen, Howard et al. (2012) Iowa dentists' involvement in care for patients who are homebound. Spec Care Dentist 32:251-8 |
| Cannon, Hyrum M; Broffitt, Barbara; Levy, Steven M et al. (2010) Longitudinal changes in parental satisfaction: mixed dentition esthetics. J Dent Child (Chic) 77:166-73 |
| Hong, Liang; Levy, Steven M; Broffitt, Barbara et al. (2006) Timing of fluoride intake in relation to development of fluorosis on maxillary central incisors. Community Dent Oral Epidemiol 34:299-309 |
| Hong, Liang; Levy, Steven M; Warren, John J et al. (2006) Fluoride intake levels in relation to fluorosis development in permanent maxillary central incisors and first molars. Caries Res 40:494-500 |
| Cho, Peter; Schneider, Galen B; Kellogg, Bradley et al. (2006) Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies. Implant Dent 15:377-85 |
| Levy, Steven M; Hong, Liang; Warren, John J et al. (2006) Use of the fluorosis risk index in a cohort study: the Iowa fluoride study. J Public Health Dent 66:92-6 |
| Hong, Liang; Watkins, Catherine A; Ettinger, Ronald L et al. (2005) Effect of topical fluoride and fluoride varnish on in vitro root surface lesions. Am J Dent 18:182-7 |
| Hong, Liang; Levy, Steven M; Warren, John J et al. (2005) Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med 159:943-8 |
| Slayton, R L; Cooper, M E; Marazita, M L (2005) Tuftelin, mutans streptococci, and dental caries susceptibility. J Dent Res 84:711-4 |
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