Little reliable data is available to guide the clinician when making many treatment decisions especially for older adults. The development of a Clinical Core for adults, senior citizens and others at high oral disease risk will provide a physical setting with appropriate expertise to help answer questions which have a bearing on prevention and treatment of oral and dental disease. The Clinical Core will have a Director, and a staff consisting of a research assistant/hygienist and a clinic clerk/dental assistant as well as two clinicians to help with specific projects. It will be located in a defined area of the Collegiate Clinics. The Core will provide access to healthy older individuals, specific patient populations and a unique group of special populations. There will be weekly meetings of Core staff to coordinate activities, review progress, and prepare for new studies. As a member of the Center Steering Committee, the Director will maintain close contact with the Experimental Design and Biostatistics and Laboratory Cores as well as with the Center Director. Initial projects will evaluate the effect of fluoride on root surface lesions and the permeability of oral mucosal lesions. The Core will be a site for faculty interested in clinical research to receive training and assistance with those aspects of their projects concerned with individuals and populations. It will encourage the development of clinical research among clinical teachers, investigators and agencies, such as industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Center Core Grants (P30)
Project #
5P30DE010126-04
Application #
3753813
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Hong, Liang; Levy, Steven M; Warren, John J et al. (2006) Fluoride intake levels in relation to fluorosis development in permanent maxillary central incisors and first molars. Caries Res 40:494-500
Cho, Peter; Schneider, Galen B; Kellogg, Bradley et al. (2006) Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies. Implant Dent 15:377-85
Levy, Steven M; Hong, Liang; Warren, John J et al. (2006) Use of the fluorosis risk index in a cohort study: the Iowa fluoride study. J Public Health Dent 66:92-6
Hong, Liang; Watkins, Catherine A; Ettinger, Ronald L et al. (2005) Effect of topical fluoride and fluoride varnish on in vitro root surface lesions. Am J Dent 18:182-7
Hong, Liang; Levy, Steven M; Warren, John J et al. (2005) Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med 159:943-8
Slayton, R L; Cooper, M E; Marazita, M L (2005) Tuftelin, mutans streptococci, and dental caries susceptibility. J Dent Res 84:711-4

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