Abstract

The Diabetes Center has been organized around seven core units--Administration Core, Biostatistics Core, Physiology Core, Radioimmunoassay Core, Clinical Research Core, Cytohistochemistry Core, and Tissue Culture Core. These are planned to support research studies by 59 affiliated investigators. They are designed to: (1) provide for better access to patients with diabetes and suitable controls and to complex animal models such as primates for diabetes-related investigation; (2) support the development, access, and efficient use of technologies relevant to diabetes; (3) coordinate, stimulate, and support collaborative studies between investigators interested in diabetes at the University of Washington; (4) provide initial support for new investigators in the field of diabetes and to stimulate the application of knowledge in related fields to study of problems in diabetes. A pilot and feasibility program of five requests for new studies in the field of diabetes is included with the application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK017047-12S2
Application #
3101929
Study Section
(SRC)
Project Start
1977-06-01
Project End
1989-03-31
Budget Start
1988-06-01
Budget End
1989-03-31
Support Year
12
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Banks, William A; Kovac, Andrej; Morofuji, Yoichi (2018) Neurovascular unit crosstalk: Pericytes and astrocytes modify cytokine secretion patterns of brain endothelial cells. J Cereb Blood Flow Metab 38:1104-1118
de Groot, Mary; Marrero, David; Mele, Lisa et al. (2018) Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program. Psychosom Med 80:167-173
Roshandel, Delnaz; Gubitosi-Klug, Rose; Bull, Shelley B et al. (2018) Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia 61:1098-1111
Hannon, Tamara S; Kahn, Steven E; Utzschneider, Kristina M et al. (2018) Review of methods for measuring ?-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium. Diabetes Obes Metab 20:14-24
Brinkley, Tina E; Anderson, Andrea; Soliman, Elsayed Z et al. (2018) Long-Term Effects of an Intensive Lifestyle Intervention on Electrocardiographic Criteria for Left Ventricular Hypertrophy: The Look AHEAD Trial. Am J Hypertens 31:541-548
Kanter, Jenny E; Kramer, Farah; Barnhart, Shelley et al. (2018) A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome. Diabetes 67:946-959
Redondo, Maria J; Geyer, Susan; Steck, Andrea K et al. (2018) TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care 41:311-317
Guillory, Bobby; Jawanmardi, Nicole; Iakova, Polina et al. (2018) Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBP?-p300/DGAT1 pathway. Aging Cell 17:
RISE Consortium (2018) Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care 41:1717-1725
Osoti, Alfred; Temu, Tecla M; Kirui, Nicholas et al. (2018) Metabolic Syndrome Among Antiretroviral Therapy-Naive Versus Experienced HIV-Infected Patients Without Preexisting Cardiometabolic Disorders in Western Kenya. AIDS Patient Care STDS 32:215-222

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