The Diabetes Research Center at the University of Washington has existed for over four decades and is part of the national program supported by NIDDK. It acts as the focal point and umbrella for diabetes research in the Greater Seattle area with the goal of promoting an environment of collaborative research on diabetes, obesity and related disorders by (1) Providing support to affiliate investigators through its biomedical research cores; (2) Conducting a pilot and feasibility program that provides grant support for new investigators in diabetes research and to established investigators in other disciplines; (3) Sponsoring an interactive enrichment program comprising lectures, retreats and symposia to inform the community of the latest developments in the area; (4) Ensuring the development of young investigators by providing postdoctoral and graduate student fellowships for salary support and training in its biomedical research cores; and (5) Developing new research methods and technologies based on the evolving needs of its investigators. To accomplish this goal, the Center is organized around five biomedical research cores (Cell Function Analysis Core, Cellular and Molecular Imaging Core, Human Studies Core, Quantitative and Functional Proteomics Core, and Vector and Transgenic Mouse Core) and an Administrative Core that also manages the Pilot and Feasibility Program and the Enrichment Program. Along with the commitment of the University of Washington and other Seattle institutions of research space and additional financial support, the Diabetes Research Center is a dynamic and constantly evolving center that supports 99 Seattle-based affiliate investigators who are making important scientific contributions in the areas of (1) Pathophysiology, prevention and treatment of type 2 diabetes; (2) Central regulation of body weight and glucose metabolism; (3) Complications of diabetes; (4) Etiology, pathogenesis and treatment of type 1 diabetes; and (5) Clinical trials and large-scale epidemiologic studies.

Public Health Relevance

The Diabetes Research Center at the University of Washington has a long-standing tradition and record of facilitating scientific investigation aimed at informing on how best to treat and prevent diabetes. Through its biomedical research cores, Pilot and Feasibility Program as well as its Enrichment Program, it will continue to support over 100 scientists in the Greater Seattle area and beyond who are pursuing basic, translation and clinical investigation in diabetes and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK017047-45
Application #
10077833
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Silva, Corinne M
Project Start
2018-02-10
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Yi-Frazier, Joyce P; Cochrane, Katie; Whitlock, Kathryn et al. (2018) Trajectories of Acute Diabetes-Specific Stress in Adolescents With Type 1 Diabetes and Their Caregivers Within the First Year of Diagnosis. J Pediatr Psychol 43:645-653
Kuzma, Jessica N; Cromer, Gail; Hagman, Derek K et al. (2018) Consuming glucose-sweetened, not fructose-sweetened, beverages increases fasting insulin in healthy humans. Eur J Clin Nutr :
Basu, Debapriya; Hu, Yunying; Huggins, Lesley-Ann et al. (2018) Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL Receptor. Circ Res 122:560-567
Alpers, Charles E; Hudkins, Kelly L (2018) Pathology identifies glomerular treatment targets in diabetic nephropathy. Kidney Res Clin Pract 37:106-111
Campos, Carlos A; Bowen, Anna J; Roman, Carolyn W et al. (2018) Encoding of danger by parabrachial CGRP neurons. Nature 555:617-622
Kim, C; Miller, R S; Braffett, B H et al. (2018) Ovarian markers and irregular menses among women with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications study. Clin Endocrinol (Oxf) 88:453-459
Wander, Pandora L; Hayashi, Tomoshige; Sato, Kyoko Kogawa et al. (2018) Design and validation of a novel estimator of visceral adipose tissue area and comparison to existing adiposity surrogates. J Diabetes Complications 32:1062-1067
Han, Seung Jin; Fujimoto, Wilfred Y; Kahn, Steven E et al. (2018) Change in visceral adiposity is an independent predictor of future arterial pulse pressure. J Hypertens 36:299-305
Wacker, Bradley K; Dronadula, Nagadhara; Bi, Lianxiang et al. (2018) Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits. Arterioscler Thromb Vasc Biol 38:206-217
Coleman, Brantley; Topalidou, Irini; Ailion, Michael (2018) Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans. Genetics 209:523-535

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