The Diabetes Research Center at the University of Washington has existed for over four decades and is part of the national program supported by NIDDK. It acts as the focal point and umbrella for diabetes research in the Greater Seattle area with the goal of promoting an environment of collaborative research on diabetes, obesity and related disorders by (1) Providing support to affiliate investigators through its biomedical research cores; (2) Conducting a pilot and feasibility program that provides grant support for new investigators in diabetes research and to established investigators in other disciplines; (3) Sponsoring an interactive enrichment program comprising lectures, retreats and symposia to inform the community of the latest developments in the area; (4) Ensuring the development of young investigators by providing postdoctoral and graduate student fellowships for salary support and training in its biomedical research cores; and (5) Developing new research methods and technologies based on the evolving needs of its investigators. To accomplish this goal, the Center is organized around five biomedical research cores (Cell Function Analysis Core, Cellular and Molecular Imaging Core, Human Studies Core, Quantitative and Functional Proteomics Core, and Vector and Transgenic Mouse Core) and an Administrative Core that also manages the Pilot and Feasibility Program and the Enrichment Program. Along with the commitment of the University of Washington and other Seattle institutions of research space and additional financial support, the Diabetes Research Center is a dynamic and constantly evolving center that supports 99 Seattle-based affiliate investigators who are making important scientific contributions in the areas of (1) Pathophysiology, prevention and treatment of type 2 diabetes; (2) Central regulation of body weight and glucose metabolism; (3) Complications of diabetes; (4) Etiology, pathogenesis and treatment of type 1 diabetes; and (5) Clinical trials and large-scale epidemiologic studies.

Public Health Relevance

The Diabetes Research Center at the University of Washington has a long-standing tradition and record of facilitating scientific investigation aimed at informing on how best to treat and prevent diabetes. Through its biomedical research cores, Pilot and Feasibility Program as well as its Enrichment Program, it will continue to support over 100 scientists in the Greater Seattle area and beyond who are pursuing basic, translation and clinical investigation in diabetes and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK017047-45
Application #
10077833
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Silva, Corinne M
Project Start
2018-02-10
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Mendoza, Jason A; Haaland, Wren; D'Agostino, Ralph B et al. (2018) Food insecurity is associated with high risk glycemic control and higher health care utilization among youth and young adults with type 1 diabetes. Diabetes Res Clin Pract 138:128-137
Vaisar, Tomas; Durbin-Johnson, Blythe; Whitlock, Kathryn et al. (2018) Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes. Diabetes Care 41:2361-2369
He, Yi; Kothari, Vishal; Bornfeldt, Karin E (2018) High-Density Lipoprotein Function in Cardiovascular Disease and Diabetes Mellitus. Arterioscler Thromb Vasc Biol 38:e10-e16
Plubell, Deanna L; Fenton, Alexandra M; Wilmarth, Phillip A et al. (2018) GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate. Sci Rep 8:11485
Ong, Kwok Leung; Morris, Margaret J; McClelland, Robyn L et al. (2018) Relationship of Lipids and Lipid-Lowering Medications With Cognitive Function: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:767-776
Liimatainen, Suvi; Honnorat, Jerome; Pittock, Sean J et al. (2018) GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies. Orphanet J Rare Dis 13:55
Marcum, Zachary A; Forsberg, Christopher W; Moore, Kathryn P et al. (2018) Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease. J Gen Intern Med 33:155-165
Templin, Andrew T; Meier, Daniel T; Willard, Joshua R et al. (2018) Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice. Diabetologia 61:2215-2224
Mukamal, Kenneth J; Siscovick, David S; de Boer, Ian H et al. (2018) Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study. J Am Geriatr Soc 66:289-296
Wall, Valerie Z; Barnhart, Shelley; Kanter, Jenny E et al. (2018) Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome. JCI Insight 3:

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