The Clinical Core ofthe Michigan Diabetes Research Center (MDRC) provides expertise and services to support basic biomedical research and research that focuses on the translation of basic science findings into potential therapeutics and their testing in eariy phase clinical trials (type 1 translational research).
The Specific Aims of the Clinical Core are: Maintain and continuously update a Diabetes Research Registry to facilitate the recruitment of diabetic subjects into clinical studies Support a Chemistry Laboratory to provide expertise and state-of-the-art analytical services to MDRC investigators Provide both routine and non-routine biostatistical services to assist MDRC investigators in experimental design, data management, and data analysis. The proposed user base for the Clinical Core are investigators engaged in basic biomedical and type 1 translational research focused on prediabetes, the pathogenesis and prevention of diabetes, diabetes treatments, and the prevention and control of diabetic complications including retinopathy, nephropathy, neuropathy and cardiovascular disease. The objective of the Clinical Core is to provide expertise and state-of-the-art shared resources to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and type 1 translational research in diabetes.

Public Health Relevance

The Clinical Core ofthe Michigan Diabetes Research Center (MDRC) provides expertise and services to support basic biomedical research and research that focuses on the translation of basic science findings into potential therapeutics and their testing in eariy phase clinical trials (type 1 translational research). The Specific Aims of the Clinical Core are: Maintain and continuously update a Diabetes Research Registry to facilitate the recruitment of diabetic subjects into clinical studies Support a Chemistry Laboratory to provide expertise and state-of-the-art analytical services to MDRC investigators Provide both routine and non-routine biostatistical services to assist MDRC investigators in experimental design, data management, and data analysis. The proposed user base for the Clinical Core are investigators engaged in basic biomedical and type 1 translational research focused on prediabetes, the pathogenesis and prevention of diabetes, diabetes treatments, and the prevention and control of diabetic complications including retinopathy, nephropathy, neuropathy and cardiovascular disease. The objective of the Clinical Core is to provide expertise and state-of-the-art shared resources to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and type 1 translational research in diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020572-36
Application #
8441328
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$147,591
Indirect Cost
$52,677
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wang, Jie-Mei; Qiu, Yining; Yang, Zhao et al. (2018) IRE1? prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Sci Signal 11:
Sung, Yun J (see original citation for additional authors) (2018) A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet 102:375-400
Allard, John B; Duan, Cunming (2018) IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? Front Endocrinol (Lausanne) 9:117
Zhang, Kezhong (2018) ""NO"" to Autophagy: Fat Does the Trick for Diabetes. Diabetes 67:180-181
Mancuso, Peter; Curtis, Jeffrey L; Freeman, Christine M et al. (2018) Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. Am J Physiol Lung Cell Mol Physiol 315:L78-L86
Kowluru, Anjaneyulu; Kowluru, Renu A (2018) RACking up ceramide-induced islet ?-cell dysfunction. Biochem Pharmacol 154:161-169
Griauzde, Dina H; Kullgren, Jeffrey T; Liestenfeltz, Brad et al. (2018) A mobile phone-based program to promote healthy behaviors among adults with prediabetes: study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud 4:48
Pan, Guodong; Munukutla, Srikar; Kar, Ananya et al. (2018) Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography. PLoS One 13:e0195796
Latva-Rasku, Aino; Honka, Miikka-Juhani; Stan?áková, Alena et al. (2018) A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study. Diabetes 67:334-342
Teslovich, Tanya M; Kim, Daniel Seung; Yin, Xianyong et al. (2018) Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. Hum Mol Genet 27:1664-1674

Showing the most recent 10 out of 1823 publications