Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
4P30DK020572-39
Application #
8988561
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
39
Fiscal Year
2016
Total Cost
$69,583
Indirect Cost
$24,835
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Bagchi, Devika P; Forss, Isabel; Mandrup, Susanne et al. (2018) SnapShot: Niche Determines Adipocyte Character I. Cell Metab 27:264-264.e1
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
O'Rourke, Robert W (2018) Adipose tissue and the physiologic underpinnings of metabolic disease. Surg Obes Relat Dis 14:1755-1763
Zhang, Kezhong; Kim, Hyunbae; Fu, Zhiyao et al. (2018) Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. Gastroenterology 154:224-237
Nahomi, Rooban B; Sampathkumar, Sruthi; Myers, Angela M et al. (2018) The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci 59:2042-2053
Taylor, D Leland; Knowles, David A; Scott, Laura J et al. (2018) Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PLoS One 13:e0195788
Johnson, Alexander W (2018) Examining the influence of CS duration and US density on cue-potentiated feeding through analyses of licking microstructure. Learn Motiv 61:85-96
Pan, David Z; Garske, Kristina M; Alvarez, Marcus et al. (2018) Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. Nat Commun 9:1512
Jiang, Lin; Su, Haoran; Keogh, Julia M et al. (2018) Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression. FASEB J 32:1830-1840
Hinder, Lucy M; Murdock, Benjamin J; Park, Meeyoung et al. (2018) Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story. Exp Neurol 305:33-43

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