The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a huge national burden of morbidity, mortality, and health care expenditures. The Michigan Diabetes Research center (MDRC) builds on the 35-year experience of the Michigan Diabetes Research and Training Center (MDRTC) as a key component of the research effort to promote new discoveries and enhance scientific progress through support of cutting-edge basic and clinical research related to the etiology and complications of diabetes. The goal of the MDRC Is to establish, promote, and enhance multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders. The missions of the MDRC are to create an environment that supports important and innovative research; raise awareness and Interest In fundamental and clinical diabetes research at affiliated Institutions and beyond; enhance diabetes research education and training opportunities for patients, students, scientists, and clinicians; attract an retain early stage Investigators and Investigators new to diabetes research; provide core services that leverage funding and unique expertise; foster interdisciplinary collaborations, especially In the emerging areas of research, to catalyze new ideas and scientific approaches; and promote the translation of scientific discoveries from bench to bedside to community to Improve public health.

Public Health Relevance

The MDRC promotes and enhances multidisciplinary and collaborative basic and clinical research relevant to diabetes, its complications, and related endocrine and metabolic disorders. This serves to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and clinical research to prevent, treat, and ultimately cure diabetes and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020572-40
Application #
9189717
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2018-02-26
Budget Start
2016-12-01
Budget End
2018-02-26
Support Year
40
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Jadoon, Adil; Mathew, Anna V; Byun, Jaeman et al. (2018) Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients. Am J Nephrol 48:269-277
Nielsen, Jonas B; Fritsche, Lars G; Zhou, Wei et al. (2018) Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet 102:103-115
Sahinoz, Melis; Khairi, Shafaq; Cuttitta, Ashley et al. (2018) Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis. Clin Diabetes Endocrinol 4:6
Fan, Yanbo; Lu, Haocheng; Liang, Wenying et al. (2018) Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. Circ Res 122:945-957
Zeng, Lixia; Mathew, Anna V; Byun, Jaeman et al. (2018) Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis. J Biol Chem 293:7238-7249
An, Duo; Chiu, Alan; Flanders, James A et al. (2018) Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes. Proc Natl Acad Sci U S A 115:E263-E272
Turcot, Valérie (see original citation for additional authors) (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:26-41
Harvey, Innocence; Stephenson, Erin J; Redd, JeAnna R et al. (2018) Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice. Endocrinology 159:2275-2287
Callaghan, Brian C; Xia, Rong; Reynolds, Evan et al. (2018) Better diagnostic accuracy of neuropathy in obesity: A new challenge for neurologists. Clin Neurophysiol 129:654-662
Ruebsam, Anne; Dulle, Jennifer E; Myers, Angela M et al. (2018) A specific phosphorylation regulates the protective role of ?A-crystallin in diabetes. JCI Insight 3:

Showing the most recent 10 out of 1823 publications