The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a huge national burden of morbidity, mortality, and health care expenditures. The Michigan Diabetes Research center (MDRC) builds on the 35-year experience of the Michigan Diabetes Research and Training Center (MDRTC) as a key component of the research effort to promote new discoveries and enhance scientific progress through support of cutting-edge basic and clinical research related to the etiology and complications of diabetes. The goal of the MDRC Is to establish, promote, and enhance multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders. The missions of the MDRC are to create an environment that supports important and innovative research; raise awareness and Interest In fundamental and clinical diabetes research at affiliated Institutions and beyond; enhance diabetes research education and training opportunities for patients, students, scientists, and clinicians; attract an retain early stage Investigators and Investigators new to diabetes research; provide core services that leverage funding and unique expertise; foster interdisciplinary collaborations, especially In the emerging areas of research, to catalyze new ideas and scientific approaches; and promote the translation of scientific discoveries from bench to bedside to community to Improve public health.

Public Health Relevance

The MDRC promotes and enhances multidisciplinary and collaborative basic and clinical research relevant to diabetes, its complications, and related endocrine and metabolic disorders. This serves to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and clinical research to prevent, treat, and ultimately cure diabetes and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK020572-40S1
Application #
9526628
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2018-02-26
Budget Start
2016-12-01
Budget End
2018-02-26
Support Year
40
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sas, Kelli M; Lin, Jiahe; Rajendiran, Thekkelnaycke M et al. (2018) Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model. J Lipid Res 59:173-183
Adams, Jessica M; Pei, Hongjuan; Sandoval, Darleen A et al. (2018) Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes 67:1538-1548
Fernandez, Carmen; DeJesus, Jasmine M; Miller, Alison L et al. (2018) Selective eating behaviors in children: An observational validation of parental report measures. Appetite 127:163-170
Zhang, Sherry; Lu, Chunxia; Das, Arun K et al. (2018) Abrogation of GH action in Kupffer cells results in increased hepatic CD36 expression and exaggerated nonalcoholic fatty liver disease. Growth Horm IGF Res 42-43:74-79
Mishra, Manish; Duraisamy, Arul J; Kowluru, Renu A (2018) Sirt1: A Guardian of the Development of Diabetic Retinopathy. Diabetes 67:745-754
Jaiswal, Mamta; Divers, Jasmin; Urbina, Elaine M et al. (2018) Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatr Diabetes 19:680-689
Rios, Peter D; Skoumal, Michael; Liu, Jeffrey et al. (2018) Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes. Biotechnol Bioeng 115:2356-2364
Zhang, Peng; Kuang, Henry; He, Yanlin et al. (2018) NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight 3:
Rosenstock, Julio; Perkovic, Vlado; Alexander, John H et al. (2018) Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardi Cardiovasc Diabetol 17:39
Kady, Nermin M; Liu, Xuwen; Lydic, Todd A et al. (2018) ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes 67:769-781

Showing the most recent 10 out of 1823 publications