The mission of the MDRC is to promote new discoveries and enhance scientific progress through the support of cutting-edge basic and clinical research by its highly interactive research base. The MDRC research base comprises 145 members: 118 members with $56.8 million of annual direct cost diabetes-related funding at the University of Michigan (UM) along with 27 regional members with $8.6 million of annual funding at three nearby Regional Partner Institutions: Michigan State University (MSU), Wayne State University (WSU) and the University of Toledo (UT). The investigators that make up the MDRC research base perform ground-breaking research in five broad areas relevant to diabetes: Cellular Aspects of Diabetes and Metabolism; Integrative Aspects of Diabetes and Metabolism; Islet Biology; Diabetic Complications; and Clinical Research in Diabetes and Metabolism. To support and empower research by its members, the MDRC will: 1. Coordinate activities that raise awareness of, interest in, and support for basic and translational research in diabetes, its complications, and related endocrine and metabolic disorders at the University of Michigan and beyond. 2. Advance learning and promote scientific exchange related to diabetes, endocrinology and metabolism. 3. Provide research cores that provide shared, specialized technical resources and expertise that enhance the efficiency, productivity, and multidisciplinary nature of research performed by MDRC investigators. 4. Support a Pilot and Feasibility studies grant program. 5. Provide support for research in diabetes, its complications, and related endocrine and metabolic disorders at Regional Partner Institutions. The MDRC provides membership, enrichment activities, an expanded Pilot and Feasibility Grant Program, and access to the MDRC Molecular Genetics Core for researchers at Regional Partner Institutions who study diabetes, its complications, and related endocrine and metabolic disorders.

Public Health Relevance

? MDRC Center Overview The MDRC oversees and provides research cores, enrichment activities and pilot and feasibility grants programs to promote new discoveries and enhance scientific progress through the support of cutting-edge basic and clinical research by its highly interactive research base, which comprises 145 members at the University of Michigan and regional partner institutions (Michigan State University (MSU), Wayne State University (WSU) and the University of Toledo (UT).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020572-44
Application #
10071159
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Silva, Corinne M
Project Start
1996-12-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
44
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Steyn, Frederik J; Ngo, Shyuan T; Chen, Vicky Ping et al. (2018) 17?-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell 17:
Schofield, Heather K; Tandon, Manuj; Park, Min-Jung et al. (2018) Pancreatic HIF2? Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 5:169-185.e2
Zhao, Xu-Yun; Xiong, Xuelian; Liu, Tongyu et al. (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986
Kim, Geun Hyang; Shi, Guojun; Somlo, Diane Rm et al. (2018) Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest 128:1125-1140
Elenbaas, Jared S; Bragazzi Cunha, Juliana; Azuero-Dajud, Rodrigo et al. (2018) Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F. Gastroenterology 154:1625-1629.e8
Herman, William H; Pan, Qing; Edelstein, Sharon L et al. (2018) Erratum. Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care 2017;40:1668-1677. Diabetes Care 41:913
Rajala, Ammaji; Wang, Yuhong; Abcouwer, Steven F et al. (2018) Developmental and light regulation of tumor suppressor protein PP2A in the retina. Oncotarget 9:1505-1523
McCabe, Laura R; Parameswaran, Narayanan (2018) Advances in Probiotic Regulation of Bone and Mineral Metabolism. Calcif Tissue Int 102:480-488
Wood, Landon; Roelofs, Karen; Koch, Lauren G et al. (2018) Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. Mol Metab 11:189-196
Kycia, Ina; Wolford, Brooke N; Huyghe, Jeroen R et al. (2018) A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. Am J Hum Genet 102:620-635

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