The Vanderbilt Diabetes Research and Training Center (VDRTC), in its 43rd continuous year of operation as a NIH-sponsored Diabetes Center, seeks to continue its efforts to facilitate the discovery, application, and translation of scientific knowledge to improve the care of patients with diabetes. The VDRTC is an interdisciplinary program involving 121 participating faculty distributed among 15 departments in two schools and three colleges at Vanderbilt and neighboring Meharry Medical College. The VDRTC consists of: 1) Administrative Component that coordinates the scientific, organizational, and outreach activities; 2) Biomedical Research Component that recruits and selects VDRTC-affiliated investigators and supervises the research cores that facilitate and enhance their research; 3) Pilot and Feasibility Program that facilitates the development of new investigators into independent scientists and encourages scientists in other fields to enter the field of diabetes research; and 4) Enrichment, Training, and Outreach Program that fosters an environment conducive to collaborative, interdisciplinary research (seminar series, Diabetes Research Day), and to training new diabetes scientists. The VDRTC oversees three NIDDK-funded diabetes-related training programs and also serves as the coordinating and organizing center for the NIDDK Medical Student Research Program which has allowed more than 550 medical students from more than 100 US medical schools to conduct diabetes-related research at one of 15 NIH-supported Diabetes Research Centers. NIH support for the VDRTC is greatly amplified by: 1) Vanderbilt's sustained commitment to provide research space and additional financial resources; 2) a diverse, comprehensive array of research core services at Vanderbilt, which allows NIH funds to target unique, diabetes-related research cores; and 3) collaborative efforts with other NIH-funded research centers at Vanderbilt. The VDRTC is evolving and dynamic, including additions to its investigator base, expansion of VDRTC research areas, expanded focus on clinical and translational research, realignment and evolution of core support to provide unique, indispensable core services, and service as a regional and national resource for the diabetes research community. Because of the VDRTC and the environment it creates, VDRTC-affiliated investigators have made important scientific contributions related to diabetes, obesity, and metabolism.

Public Health Relevance

Center Overview: Project Narrative The Vanderbilt Diabetes Research and Training Center is working to understand why diabetes develops, how it can be prevented, and how diabetes treatment can be improved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020593-40
Application #
9330507
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J1)P)
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2022-03-31
Budget Start
2017-06-16
Budget End
2018-03-31
Support Year
40
Fiscal Year
2017
Total Cost
$1,866,602
Indirect Cost
$522,430
Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318
Herrick, Mary K; Favela, Kristin M; Simerly, Richard B et al. (2018) Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice. Mol Med 24:56
Martinez 2nd, Keith A; Romano-Keeler, Joann; Zackular, Joseph P et al. (2018) Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice. PLoS One 13:e0197439
Perez, Katia M; Curley, Kathleen L; Slaughter, James C et al. (2018) Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab 103:4265-4274
Saunders, Diane C; Brissova, Marcela; Phillips, Neil et al. (2018) Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In Vitro and In Vivo Analysis. Cell Metab :
Marre, Meghan L; McGinty, John W; Chow, I-Ting et al. (2018) Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes 67:1356-1368
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Wang, Feng; Katagiri, Daisuke; Li, Ke et al. (2018) Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80:2655-2669
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129

Showing the most recent 10 out of 697 publications