Abstract

(taken from application): This component of the Membrane Biology Core has two major functions: A) assisting DERC investigators in the analysis of cellular signal transduction pathways and providing common reagents and antibodies for studies related to signal transduction pathways; and B) large scale production of MSA, and purification of antibodies to IGF, insulin receptors and other proteins used in studies of signal transduction pathways.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK025295-23
Application #
6564188
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
$211,312
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Harding, Anne Marie S; Kusama, Nobuyoshi; Hattori, Tomonori et al. (2014) ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95. PLoS One 9:e93797
Kusama, Nobuyoshi; Gautam, Mamta; Harding, Anne Marie S et al. (2013) Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition. Am J Physiol Cell Physiol 304:C89-101
Collier, Daniel M; Peterson, Zerubbabel J; Blokhin, Ilya O et al. (2012) Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH. J Biol Chem 287:40907-14
Herlein, Judith A; Fink, Brian D; Henry, Dorlyne M et al. (2011) Mitochondrial superoxide and coenzyme Q in insulin-deficient rats: increased electron leak. Am J Physiol Regul Integr Comp Physiol 301:R1616-24
Herlein, Judy A; Fink, Brian D; Sivitz, William I (2010) Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes. Metabolism 59:247-57
Sivitz, William I; Yorek, Mark A (2010) Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal 12:537-77
Elliott, David E; Weinstock, Joel V (2009) Helminthic therapy: using worms to treat immune-mediated disease. Adv Exp Med Biol 666:157-66
Herlein, Judith A; Fink, Brian D; O'Malley, Yunxia et al. (2009) Superoxide and respiratory coupling in mitochondria of insulin-deficient diabetic rats. Endocrinology 150:46-55
Hattori, Tomonori; Chen, Jie; Harding, Anne Marie S et al. (2009) ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ Res 105:279-86
Fink, Brian D; O'Malley, Yunxia; Dake, Brian L et al. (2009) Mitochondrial targeted coenzyme Q, superoxide, and fuel selectivity in endothelial cells. PLoS One 4:e4250

Showing the most recent 10 out of 690 publications