Abstract

The role of the centralized Morphology Core is to assist affiliated Diabetes and Endocrinology Research Center investigators who require morphology-related evaluation of cells and tissues. The resources available through the Morphology Core include light and electron microscopy techniques, such as routine histology, cryotomy, immunohistochemistry, autoradiography and also routine transmission electron microscopy, immunoelectron microscopy and autoradiography. These techniques may be further adapted to suit projects with special requirements. Consultation with principal investigators regarding methods of sampling, fixation and diagnostic service is also offered. Drawing on all these approaches, the Morphology Core offers a complete gross and microscopic diagnostic service to help investigators by adding- where needed- the dimension of morphology to their research protocols.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK032520-16S2
Application #
6219005
Study Section
Project Start
1999-12-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Desai, Paurav B; San Agustin, Jovenal T; Stuck, Michael W et al. (2018) Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev 151:10-17
Ly, Socheata; Navaroli, Deanna M; Didiot, Marie-Cécile et al. (2017) Visualization of self-delivering hydrophobically modified siRNA cellular internalization. Nucleic Acids Res 45:15-25
Wang, Feng; McCannell, Kurtis N; Boškovi?, Ana et al. (2017) Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep 21:3691-3699
Watkin, Levi B; Mishra, Rabinarayan; Gil, Anna et al. (2017) Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion. J Allergy Clin Immunol 140:1206-1210
LeBlanc, Scott E; Wu, Qiong; Lamba, Pallavi et al. (2016) Promoter-enhancer looping at the PPAR?2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res 44:5133-47
Wang, Feng; Shin, JongDae; Shea, Jeremy M et al. (2016) Regulation of X-linked gene expression during early mouse development by Rlim. Elife 5:
Kincaid, Eleanor Z; Murata, Shigeo; Tanaka, Keiji et al. (2016) Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells. Nat Immunol 17:938-45
Townsley, E; O'Connor, G; Cosgrove, C et al. (2016) Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells. Clin Exp Immunol 183:419-30
Wyss, Lena; Stadinski, Brian D; King, Carolyn G et al. (2016) Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol 17:1093-101
Delong, Thomas; Wiles, Timothy A; Baker, Rocky L et al. (2016) Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science 351:711-4

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