The HDDC Pilot-Feasibility (P/F) Grant Program is a centerpiece of HDDC activities with an important impact on future advances in digestive disease research. The P/F Program provides funding ($25 K for 1 year) that primarily targets young investigators in the process of establishing their independent research careers, but also allows established investigators to initiate innovative and promising pilot projects that could lead to substantial funding for new lines of research relevant to digestive diseases.
The Specific Aims of the HDDC P/F Program are: 1. To support and encourage young and mentored investigators in digestive disease-related research who have not previously held independent awards (Type I Awards). 2. To entice accomplished investigators from other fields who are not currently focused on digestive diseases to apply new concepts and technical approaches to the digestive tract (Type II awards). 3. To enable established investigators already working in digestive disease-related research to initiate a substantial, innovative change in the direction of their research (Type III awards). The HDDC selects these projects through a rigorous multi-step process modeled on NIH study sections. Proposals are scored on the basis of innovation, scientific merit and the potential for future independent funding in digestive disease research. The success rate of PF awardees in obtaining subsequent grant support has been outstanding. Since 2006 45 investigators have been supported by HDDC P/F grants including 4 current grantees. Of the 41 previous PF awardees, 39 (95 %) subsequently won independent grant funding and all previous grantees but one are still engaged in digestive disease-related research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034854-31
Application #
8971195
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
31
Fiscal Year
2016
Total Cost
$191,725
Indirect Cost
$77,000
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
McSweeney, Maireade E; Kerr, Jessica; Amirault, Janine et al. (2018) Preoperative Evaluation Is Not Predictive of Transpyloric Feeding Conversion in Gastrostomy-dependent Pediatric Patients. J Pediatr Gastroenterol Nutr 66:887-892
Thiagarajah, Jay R; Kamin, Daniel S; Acra, Sari et al. (2018) Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 154:2045-2059.e6
Masuyer, Geoffrey; Zhang, Sicai; Barkho, Sulyman et al. (2018) Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity. Sci Rep 8:4518
Xenakis, Jason J; Howard, Emily D; Smith, Kalmia M et al. (2018) Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology 154:298-308
Desai, Anal; Alves-Bezerra, Michele; Li, Yingxia et al. (2018) Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. J Lipid Res 59:368-379
Richmond, Camilla A; Rickner, Hannah; Shah, Manasvi S et al. (2018) JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports 10:17-26
Rankin, Carl Robert; Theodorou, Evangelos; Man Law, Ivy Ka et al. (2018) Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 315:G722-G733
Garcia-Castillo, Maria Daniela; Lencer, Wayne I; Chinnapen, Daniel J-F (2018) Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc 8:
Richardson, Gavin David; Sage, Andrew; Bennaceur, Karim et al. (2018) Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol 38:1283-1296
Hong, Shangyu; Song, Wei; Zushin, Peter-James H et al. (2018) Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab 12:25-38

Showing the most recent 10 out of 869 publications