Abstract

(Taken from the application) This is a new core. The rationale for the core is to contribute both a ready supply of specific viral vector reagents and the expertise needed to develop the vector technology to keep pace with the growing experience in gene delivery to target cells.
The specific aims are 1. To generate adenovirus (Ad), adeno-associated virus (AAV) and retroviral vectors carrying reporter and specific genes for the center members; 2. To prepare, stockpile and distribute viral vectors constructed at the UNC as well as obtain other published vectors of interest for production and distribution; and 3. To continue to develop new methods of production and purification (e.g.. Ad-free AAV) as well as novel vectors (non-human lentiviral) that will provide researchers with high quality and efficient delivery systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK034987-17S1
Application #
6666359
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
17
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Pollard, Katharine L; Campbell, Christina; Squires, Megan et al. (2018) Seasonal Association of Pediatric Functional Abdominal Pain Disorders and Anxiety. J Pediatr Gastroenterol Nutr 67:18-22
Weiser, Matthew; Simon, Jeremy M; Kochar, Bharati et al. (2018) Molecular classification of Crohn's disease reveals two clinically relevant subtypes. Gut 67:36-42
Kaelberer, Melanie Maya; Buchanan, Kelly L; Klein, Marguerita E et al. (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361:
Ellermann, Melissa; Sartor, R Balfour (2018) Intestinal bacterial biofilms modulate mucosal immune responses. J Immunol Sci 2:13-18
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Kochar, Bharati; Barnes, Edward L; Long, Millie D et al. (2018) Depression Is Associated With More Aggressive Inflammatory Bowel Disease. Am J Gastroenterol 113:80-85
Dong, Jing; Buas, Matthew F; Gharahkhani, Puya et al. (2018) Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Gastroenterology 154:1273-1281.e3
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Carlson, Alexander L; Xia, Kai; Azcarate-Peril, M Andrea et al. (2018) Infant Gut Microbiome Associated With Cognitive Development. Biol Psychiatry 83:148-159
Azcarate-Peril, M Andrea; Butz, Natasha; Cadenas, Maria Belen et al. (2018) An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome. Appl Environ Microbiol 84:

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