The members of the Center for Gastrointestinal Biology and Disease (CGIBD) are basic and clinical scientists from diverse disciplines dedicated to advancing our understanding of gastrointestinal biology, physiology and epidemiology with a special emphasis on inflammatory bowel diseases. The overarching hypothesis that integrates the scientific activities of CGIBD members is that most digestive and hepatic diseases are the result of complex interactions between host genetic susceptibility, and environmental stimuli. The theme that links the research of center members is gene-environment interactions in gastrointestinal and liver disease. The goal of the Center is to promote and enhance multidisciplinary and translational digestive disease research. The Center achieves this goal through: 1) core facilities that provide training, technical support, laboratory animals, biostatistical and data management support, assays, imaging, and vectors;2) a pilot feasibility program that offers startup funds to junior investigators, or to established investigators who wish to pursue a new research direction;3) a scientific enrichment program consisting of seminars, symposia and workshops to improve the intellectual climate for digestive disease research and to promote cooperation, collaboration and communication among involved personnel;4) a professional development and training program that fosters the careers of junior faculty. To support the research of members, the center proposes the following cores: 1) Biostatistics and Data Management;2) Proteomics/Immunotechnologies 3) Imaging (confocal microscopy, histology);4) Vector;and 5) Gnotobiotic Animal. These cores have evolved in response to new scientific directions of center members and new investigative opportunities. Significant new additions include an expanded Gnotobiotic Animal Core, central breeding and genotyping of mutant mice, a proteomics component to the Immunotechnologies Core, and a self-contained histology facility. Gastrointestinal diseases and their complications have a significant health and economic impact. Research by members of this center has led to fundamental breakthroughs in our understanding of mechanisms responsible for inflammatory bowel diseases, cirrhosis, irritable bowel syndrome, and gastrointestinal cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK034987-24S1
Application #
7864716
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Podskalny, Judith M,
Project Start
1996-12-01
Project End
2010-05-31
Budget Start
2009-07-25
Budget End
2010-05-31
Support Year
24
Fiscal Year
2009
Total Cost
$298,017
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Keith, Benjamin P; Barrow, Jasmine B; Toyonaga, Takahiko et al. (2018) Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. JCI Insight 3:
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Jacob, Noam; Jacobs, Jonathan P; Kumagai, Kotaro et al. (2018) Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol 11:1466-1476
Peery, Anne F; Keku, Temitope O; Addamo, Cassandra et al. (2018) Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms. Clin Gastroenterol Hepatol 16:884-891.e1
Kochar, Bharati; Barnes, Edward L; Herfarth, Hans H et al. (2018) Asians have more perianal Crohn disease and ocular manifestations compared with white Americans. Inflamm Intest Dis 2:147-153

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