Abstract

application):
The aim of the Genetics and Animal Models Core is to integrate the concepts and methods of genetics into nutrition studies in humans and animals. The genome project has provided the basic tools needed to accomplish these goals, including genetic markers that can be used for rapid determination of the chromosomal location of genes for simple and complex traits; a catalog of 90% of all genes expressed by mice and humans; chromosomal locations for thousands of genetic diseases of humans and mice; and chromosomal locations for 40% of all expressed genes. Tools are now being developed to quantitate expression levels of thousands of genes at a time. Animal models provide many advantages for genetic studies, including the availability of spontaneous and induced mutants and control of diet, environment, breeding, and tissue collection. Thus, the interactions of nutrition and genetics can be investigated quickly and thoroughly in animal models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK035747-15
Application #
6301101
Study Section
Project Start
2000-03-28
Project End
2000-11-30
Budget Start
Budget End
Support Year
15
Fiscal Year
2000
Total Cost
$276,667
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Yuen, Tony; Choi, Soon Gang; Pincas, Hanna et al. (2012) Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Mol Cell Endocrinol 350:10-9
Garcia-Arocena, Dolores; Yang, Jane E; Brouwer, Judith R et al. (2010) Fibroblast phenotype in male carriers of FMR1 premutation alleles. Hum Mol Genet 19:299-312
Chowanadisai, Winyoo; Bauerly, Kathryn A; Tchaparian, Eskouhie et al. (2010) Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem 285:142-52
Liao, Y; Lonnerdal, B (2010) miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period. Int J Biochem Cell Biol 42:1363-9
Liao, Y; Lönnerdal, B (2010) Beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation. Cell Mol Life Sci 67:2969-78
Liao, Yalin; Lonnerdal, Bo (2010) Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation. PLoS One 5:e12976
Ellis-Hutchings, Robert G; Cherr, Gary N; Hanna, Lynn A et al. (2009) The effects of marginal maternal vitamin A status on penta-brominated diphenyl ether mixture-induced alterations in maternal and conceptal vitamin A and fetal development in the Sprague Dawley rat. Birth Defects Res B Dev Reprod Toxicol 86:48-57
Lönnerdal, B; Kelleher, S L (2009) Micronutrient transfer: infant absorption. Adv Exp Med Biol 639:29-40
Kelleher, S L; Lönnerdal, B (2009) Nutrient transfer: mammary gland regulation. Adv Exp Med Biol 639:15-27
Kopp, Artyom; Barmina, Olga; Hamilton, Andrew M et al. (2008) Evolution of gene expression in the Drosophila olfactory system. Mol Biol Evol 25:1081-92

Showing the most recent 10 out of 325 publications