Abstract

Objective: To provide and facilitate morphological evaluation to DERC investigators. The goal has been to have sophisticated morphological techniques readily available to all investigators at this Center by providing electron microscopic services and a confocal microscope facility. In addition, the Core has been a resource for protocols, analysis and interpretation, and equipment for paraffin and cryostat sectioning. With the increased use of transgenic and null mice, the need for paraffin embedding/sectioning and cryostat sectioning has become greater. Understanding these mice has mandated histological assessment of many tissues initially and then specific tissues in greater detail. In the past most investigators have sent their samples out to other institutions for these services. In answer to this demand, we have added a Histology component to this Core by expanding the personnel, equipment and space for the Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK036836-16
Application #
6501730
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1986-09-30
Project End
2007-03-31
Budget Start
Budget End
Support Year
16
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Katz, Michelle L; Guo, Zijing; Cheema, Alina et al. (2018) Management of Cardiovascular Disease Risk in Teens with Type 1 Diabetes: Perspectives of Teens With and Without Dyslipidemia and Parents. Pediatr Diabetes :
Rezanejad, Habib; Ouziel-Yahalom, Limor; Keyzer, Charlotte A et al. (2018) Heterogeneity of SOX9 and HNF1? in Pancreatic Ducts Is Dynamic. Stem Cell Reports 10:725-738
Teló, G H; Dougher, C E; Volkening, L K et al. (2018) Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes. Diabet Med 35:1355-1363
Gordin, Daniel; Harjutsalo, Valma; Tinsley, Liane et al. (2018) Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 41:815-822
Goldford, Joshua E; Lu, Nanxi; Baji?, Djordje et al. (2018) Emergent simplicity in microbial community assembly. Science 361:469-474
Srinivasan, Shylaja; Kaur, Varinderpal; Chamarthi, Bindu et al. (2018) TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care 41:554-561
Karst, Sonja G; Lammer, Jan; Radwan, Salma H et al. (2018) Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Int J Endocrinol 2018:7492946
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491

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