Abstract

The Animal Physiology Core provides services to characterize the physiological parameters of rodent models of diabetes, obesity and their associated complications. These services include measurements in the categories of energy homeostasis, energy expenditure during exercise, vascular studies, ischemic tissue studies and glucose homeostasis. Energy Homeostasis: Feeding/drinking behavior, body composition, oxygen consumption and activity monitoring (CLAMS and DEXA). Energy Expenditure During Exercise: Oxygen consumption during rodent treadmill running (TM). Vascular Studies: Blood pressure measurements by tail blood pressure cuffs and by telemetry (BP). Ischemic Tissue Studies: The OxyCycler (OC) is an in vivo system that controls the ambient oxygen concentration allowing investigation of the effects of hypoxia or hyperoxia on various organs and tissues. Glucose Homeostasis: Monitoring of blood glucose and insulin levels, intraperitoneal glucose tolerance tests (GTT), insulin tolerance tests (ITT). Available upon request by an investigator for teaching purposes only.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-25
Application #
8249912
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2012-08-31
Budget Start
2011-04-01
Budget End
2013-03-31
Support Year
25
Fiscal Year
2011
Total Cost
$160,767
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Rezanejad, Habib; Ouziel-Yahalom, Limor; Keyzer, Charlotte A et al. (2018) Heterogeneity of SOX9 and HNF1? in Pancreatic Ducts Is Dynamic. Stem Cell Reports 10:725-738
Katz, Michelle L; Guo, Zijing; Cheema, Alina et al. (2018) Management of Cardiovascular Disease Risk in Teens with Type 1 Diabetes: Perspectives of Teens With and Without Dyslipidemia and Parents. Pediatr Diabetes :
Gordin, Daniel; Harjutsalo, Valma; Tinsley, Liane et al. (2018) Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 41:815-822
Teló, G H; Dougher, C E; Volkening, L K et al. (2018) Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes. Diabet Med 35:1355-1363
Srinivasan, Shylaja; Kaur, Varinderpal; Chamarthi, Bindu et al. (2018) TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care 41:554-561
Goldford, Joshua E; Lu, Nanxi; Baji?, Djordje et al. (2018) Emergent simplicity in microbial community assembly. Science 361:469-474
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Karst, Sonja G; Lammer, Jan; Radwan, Salma H et al. (2018) Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Int J Endocrinol 2018:7492946
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696

Showing the most recent 10 out of 1120 publications