Abstract

application) This core is designed to provide cost effective immunology research services to center investigators, serves as a repository for reagents such as hybridomas, and provides education in the use of educational techniques. The range of techniques provided includes preparation of monoclonal antibodies, protein analysis, flow cytometry (FACSCAN), purification of IELs and LPLs, T and B lymphocyte function assays, ELISA and RIAs, and assays of cytokines. The core has two locations. The primary location is at MGH east, where two benches and shared resources are dedicated to the center, and a second location at MGH is dedicated to monoclonal preparation. The core director is Dr. Allan Walker, with co directors Dr. Nagler-Anderson at MGH east and Dr. Takahashi at MGH. There is a 100% technician at MGH east whose primary work is to support flow cytometry and T and B cell assays, and a 50% technician at MGH to produce monoclonal antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK043351-12
Application #
6564268
Study Section
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
12
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Moretti, Francesca; Bergman, Phil; Dodgson, Stacie et al. (2018) TMEM41B is a novel regulator of autophagy and lipid mobilization. EMBO Rep 19:
Kim, Young-In; Song, Joo-Hye; Ko, Hyun-Jeong et al. (2018) CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production. J Immunol 201:1287-1294
Ma, Wenjie; Jovani, Manol; Liu, Po-Hong et al. (2018) Association Between Obesity and Weight Change and Risk of Diverticulitis in Women. Gastroenterology 155:58-66.e4
Domman, Daryl; Chowdhury, Fahima; Khan, Ashraful I et al. (2018) Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh. Nat Genet 50:951-955
Rivas, Manuel A; Avila, Brandon E; Koskela, Jukka et al. (2018) Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet 14:e1007329
DeBoever, Christopher; Tanigawa, Yosuke; Lindholm, Malene E et al. (2018) Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun 9:1612
Borren, Nienke Z; Conway, Grace; Garber, John J et al. (2018) Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases. J Crohns Colitis 12:525-531
Qu, Chen; Zheng, Dandan; Li, Sai et al. (2018) Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis. Hepatology :
Simon, Tracey G; King, Lindsay Y; Chong, Dawn Q et al. (2018) Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies. Hepatology 67:1797-1806
Chandradas, Sajiv; Khalili, Hamed; Ananthakrishnan, Ashwin et al. (2018) Does Obesity Influence the Risk of Clostridium difficile Infection Among Patients with Ulcerative Colitis? Dig Dis Sci 63:2445-2450

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