application) This core is designed to provide cost effective immunology research services to center investigators, serves as a repository for reagents such as hybridomas, and provides education in the use of educational techniques. The range of techniques provided includes preparation of monoclonal antibodies, protein analysis, flow cytometry (FACSCAN), purification of IELs and LPLs, T and B lymphocyte function assays, ELISA and RIAs, and assays of cytokines. The core has two locations. The primary location is at MGH east, where two benches and shared resources are dedicated to the center, and a second location at MGH is dedicated to monoclonal preparation. The core director is Dr. Allan Walker, with co directors Dr. Nagler-Anderson at MGH east and Dr. Takahashi at MGH. There is a 100% technician at MGH east whose primary work is to support flow cytometry and T and B cell assays, and a 50% technician at MGH to produce monoclonal antibodies.
Akcakaya, Pinar; Bobbin, Maggie L; Guo, Jimmy A et al. (2018) In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561:416-419 |
Kim, Byeong-Moo; Abdelfattah, Ahmed Maher; Vasan, Robin et al. (2018) Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis. Sci Rep 8:7499 |
Yassour, Moran; Jason, Eeva; Hogstrom, Larson J et al. (2018) Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe 24:146-154.e4 |
Perugino, Cory A; AlSalem, Sultan B; Mattoo, Hamid et al. (2018) Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. J Allergy Clin Immunol : |
Yurchenko, Maria; Skjesol, Astrid; Ryan, Liv et al. (2018) SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol 217:1411-1429 |
Burke, Kristin E; Ananthakrishnan, Ashwin N; Lochhead, Paul et al. (2018) Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. J Crohns Colitis 12:559-567 |
Ma, Wenjie; Jovani, Manol; Liu, Po-Hong et al. (2018) Association Between Obesity and Weight Change and Risk of Diverticulitis in Women. Gastroenterology 155:58-66.e4 |
Moretti, Francesca; Bergman, Phil; Dodgson, Stacie et al. (2018) TMEM41B is a novel regulator of autophagy and lipid mobilization. EMBO Rep 19: |
Kim, Young-In; Song, Joo-Hye; Ko, Hyun-Jeong et al. (2018) CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production. J Immunol 201:1287-1294 |
DeBoever, Christopher; Tanigawa, Yosuke; Lindholm, Malene E et al. (2018) Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun 9:1612 |
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