The major roles of the Molecular Biology Core are (1) to provide services in the utilization of molecular biologicaltechniques and (2) to facilitate the implementation of advances in molecular biology to IBD research. Applicationof molecular biological approaches is central to the evaluation of processes underlying the development of IBDaccording to the hypotheses that serve as a foundation for this Center. These approaches include evaluation of themechanisms for maintaining epithelial function and integrity, factors regulating immune activation and processescontributing to amplification of inflammatory responses and tissue injury [1]. Most importantly, molecularbiological approaches are essential in the study of innate immunity, host:microbial interactions at the mucosalinterface, dendritic cell/immune cell interactions, human genetic evaluation and murine models of IBD, areaswhich form key components of IBD-related research in the next support period[2-8]. It is apparent from thedescription of the CSIBD research base that most Center investigators use basic molecular biological techniques as afundamental component of their research projects. These techniques permit the identification and characterization ofgenes regulating epithelial and immune cell function, analysis of the expression of these genes, determination of thefunctions aid interactions of tie encoded proteins, expression of reporter genes and proteins to allow cellular localization and physiological analysis.
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