The Human Genetics and Microbiome Core will be co-directed by Mark Daly and Curtis Huttenhower. The services offered within this core are composed of a suite of services from more routine and heavily used molecular biology services (e.g., whole plasmid DNA sequencing) to computationally complex tools to analyze the role of genetics and the microbiome in IBD (e.g., statistical association testing between host genotypes and microbiome).Central to all services are formal and informal end-to-end consultations and training on experimental design, data generation, and bioinformatics analysis. A team of bioinformaticists and software developers with in-depth expertise are available within the Core to provide collaborative capacity for analysis of genetics, microbiome, and/or functional data This core will be a major connection point for clinicians and basic researchers, as it operates at the intersection between patient samples and basic research techniques.
The specific aims of Human Genetics and Microbiome Core are divided according to its two themes. For genetics, the Core will (1) facilitate the application of advanced experimental platforms for genetics, genomics, and high-throughput data analysis to discovery efforts relevant to IBD; (2) provide a centralized facility and personnel for performing state-of-the-art recombinant and PCR-based DNA procedures and RNA interference and provide cost-effective and high- quality molecular biology reagents and services; and (3) provide a resource for disseminating a wide range of molecular biology, genetic, and bioinformatics technologies. For microbiome services, the Core will (1) provide an end-to-end sampling and multi?omic profiling system for the host and microbiota in IBD and gastrointestinal disease; (2) provide computational resources to analyze and interpret the microbiome; and (3) develop cutting-edge solutions in microbiome research that will drive therapeutic discovery.
| Akcakaya, Pinar; Bobbin, Maggie L; Guo, Jimmy A et al. (2018) In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561:416-419 |
| Kim, Byeong-Moo; Abdelfattah, Ahmed Maher; Vasan, Robin et al. (2018) Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis. Sci Rep 8:7499 |
| Yassour, Moran; Jason, Eeva; Hogstrom, Larson J et al. (2018) Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe 24:146-154.e4 |
| Perugino, Cory A; AlSalem, Sultan B; Mattoo, Hamid et al. (2018) Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. J Allergy Clin Immunol : |
| Yurchenko, Maria; Skjesol, Astrid; Ryan, Liv et al. (2018) SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol 217:1411-1429 |
| Burke, Kristin E; Ananthakrishnan, Ashwin N; Lochhead, Paul et al. (2018) Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. J Crohns Colitis 12:559-567 |
| Ma, Wenjie; Jovani, Manol; Liu, Po-Hong et al. (2018) Association Between Obesity and Weight Change and Risk of Diverticulitis in Women. Gastroenterology 155:58-66.e4 |
| Moretti, Francesca; Bergman, Phil; Dodgson, Stacie et al. (2018) TMEM41B is a novel regulator of autophagy and lipid mobilization. EMBO Rep 19: |
| Kim, Young-In; Song, Joo-Hye; Ko, Hyun-Jeong et al. (2018) CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production. J Immunol 201:1287-1294 |
| DeBoever, Christopher; Tanigawa, Yosuke; Lindholm, Malene E et al. (2018) Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun 9:1612 |
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