The Yale Diabetes Endocrinology Research Center brings together a multidisciplinary group of independent principal investigators as well as professional supporting staff, young investigators and research trainees from the Departments of Internal Medicine, Pediatrics, Immunobiology, Cell Biology, Molecular Biophysics and Biochemistry, Genetics, Pharmacology, Physiology, Pathology, Surgery, Obstetrics and Gynecology, Biology, Neurology, Neurosurgery, Psychology and from the Schools of Nursing and Public Health. The research activities of the Center members are broad and range from basic cellular and molecular biology to whole body clinical physiology in diabetic patients. The members are, however, linked by their common interest and active participation in research dealing with diabetes mellitus or related metabolic and endocrine disorders. The cornerstone of the Center is its Research Cores that provide funded scientists with the opportunity to more efficiently utilize resources and to expand the scope of their programs. The Cores focus on three major themes: 1) Molecular Biology; 2) Cell Biology and Immunobiology, and 3) Clinical Metabolism. An Administrative Core oversees the operation of the Center and its Pilot and Feasibility Project Program and helps to coordinate patient-based diabetes research throughout the institution. The principal goals of the Center are to: 1) stimulate multidisciplinary interactions, particularly between basic and clinical scientists; 2) efficiently organize time consuming and/or costly techniques through Core facilities to enhance the productivity of investigators conducting research in diabetes or in related areas; 3) promote new research programs through pilot/feasibility projects; 4) enhance the quality of research training, and 5) create an institutional environment that amplifies and expands research efforts in diabetes or related metabolic and endocrine disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK045735-03
Application #
2144961
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1995-02-04
Budget End
1995-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Belfort-DeAguiar, Renata; Gallezot, Jean-Dominique; Hwang, Janice J et al. (2018) Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. J Clin Endocrinol Metab 103:2244-2252
Tricò, Domenico; Natali, Andrea; Mari, Andrea et al. (2018) Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents. Diabetes Obes Metab 20:2905-2910
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Hwang, Janice Jin; Parikh, Lisa; Lacadie, Cheryl et al. (2018) Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. J Clin Invest 128:1485-1495
Wang, Yongliang; Nasiri, Ali R; Damsky, William E et al. (2018) Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Rep 24:47-55
RISE Consortium (2018) Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care 41:1717-1725
Tan, Qiyuan; Tai, Ningwen; Li, Yangyang et al. (2018) Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3:
Madiraju, Anila K; Qiu, Yang; Perry, Rachel J et al. (2018) Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med 24:1384-1394
Goldberg, Ira J; Reue, Karen; Abumrad, Nada A et al. (2018) Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation 138:305-315

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