Abstract

The objectives of this core are to provide: 1. A service facility that wil utilize investigator-derived DNA constructs to create founder transgenic and gene knockout mice that can be used to address questions relevant to obesity and nutrition research; 2. Consultations to obesity and nutrition researchers regarding general aspects of transgenic and gene knockout work, the use of tissue-specific promoters, the generation of transgenic and gene knockout constructs, and the establishment and monitoring of genetically modified mouse colonies; and 3. Training in methods required for the generation of transgenic and gene knockout DNA constructs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
7P30DK046200-07
Application #
6105543
Study Section
Project Start
1998-09-30
Project End
1999-09-29
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Gaskins, Audrey J; Chavarro, Jorge E (2018) Diet and fertility: a review. Am J Obstet Gynecol 218:379-389
Goni, Leticia; Sun, Dianjianyi; Heianza, Yoriko et al. (2018) A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial. Eur J Nutr :
Wang, Yuanguo; Wang, Shaohui; Kelly, Ciaran P et al. (2018) TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection. Infect Immun 86:
Bao, Wei; Song, Yiqing; Bertrand, Kimberly A et al. (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study. J Diabetes 10:373-379
Thomas, Dylan D; Anderson, Wendy A; Apovian, Caroline M et al. (2018) Weight Recidivism After Roux-en-Y Gastric Bypass Surgery: An 11-Year Experience in a Multiethnic Medical Center. Obesity (Silver Spring) :
Kornides, Melanie L; Gillman, Matthew W; Rosner, Bernard et al. (2018) US adolescents at risk for not meeting physical activity recommendations by season. Pediatr Res 84:50-56
Yu, Edward; Malik, Vasanti S; Hu, Frank B (2018) Cardiovascular Disease Prevention by Diet Modification: JACC Health Promotion Series. J Am Coll Cardiol 72:914-926
Marron, Elena M; Viejo-Sobera, Raquel; Cuatrecasas, Guillem et al. (2018) Prefronto-cerebellar neuromodulation affects appetite in obesity. Int J Obes (Lond) :
Dong, Kimberly R; Must, Aviva; Tang, Alice M et al. (2018) Food Insecurity, Morbidities, and Substance Use in Adults on Probation in Rhode Island. J Urban Health 95:564-575

Showing the most recent 10 out of 876 publications