The purpose of BNORC's Pilot and Feasibility (P&F) Program is to foster the development of significant and innovative obesity and nutrition-related research among the trainees and faculty at medical and scientific institutions in the greater Boston area. Process of evaluation: BNORC's P&F award process involves rigorous peer review in two phases. One- page Letters of Intent are solicited by a Call for Applications. Eligible applicants fall into one of three categories: 1) new investigators without current or past independent research support (e.g., NIH R01 grants), (2) established, funded investigators with no previous work in obesity or nutrition-related areas who wish to apply their expertise to an obesity or nutrition-related problem, or (3) established investigators who wish to test the feasibility of a new or innovative idea that represents a significant and clear departure from their funded research. After an initial review, applicants who meet eligibility criteria and whose proposals are judged to have clear scientific merit are invited to submit full proposals for 1 year of funding with the opportunity to submit one renewal. Scientific review of P&F applications is conducted by a Scientific Review Committee that includes all members of the BNORC Executive Committee and the BNORC Scientific Advisory Committee, as well as selected other senior investigator members of BNORC and outside investigators with specific relevant expertise. We have also formed a P&F subcommittee that assists in the final deliberation for review of LOI and full applications. Recent accomplishments of the P&F Program: Over the last 10 years, 50% of newly P&F funded investigators have received NIH funding while in total 66% of these newly funded P&F investigators have gone on to obtain federal, foundation and institutional support. Since this current funding cycle began in 2013 and up till 2015, there have been 13 new awards to support both basic science and clinical/epidemiological projects. Of the 13 new awardees since 2013 100% were new investigators. Seventy percent of awardees were from a Harvard affiliated institution, 23% were from Boston University School of Medicine, and 8% from Tufts. Harvard affiliated applicants represent seven different institutions. During the summer of 2016, we had a call for P&F letters of intent (LOI) to be submitted by September 7. We received 37 LOI applications with 33 applications from new investigators and 18 of the applicants were invited to submit full applications by December 1. With regard to outcomes of P&F grantees from 2013 to present, 44% of P&F grantees, have received total direct funding of $8,196,407, a leveraging of approximately 8 to 9 times of P&F funding. Of newly funded P&F grants since 2013, total funding obtained was $1,641,045. From the current funding cycle P&F investigators have published 17 peer-reviewed articles related to their P&F awards.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK046200-28
Application #
9936252
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
28
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Killion, Elizabeth A; Reeves, Andrew R; El Azzouny, Mahmoud A et al. (2018) A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab 9:43-56
Leitner, Brooks P; Weiner, Lauren S; Desir, Matthew et al. (2018) Kinetics of human brown adipose tissue activation and deactivation. Int J Obes (Lond) :
Gaskins, Audrey J; Rich-Edwards, Janet W; Williams, Paige L et al. (2018) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur J Nutr 57:107-117
Hansen, S; Halldorsson, T I; Olsen, S F et al. (2018) Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk. Int J Obes (Lond) 42:15-19
Maldonado-Cárceles, Ana B; Mínguez-Alarcón, Lidia; Mendiola, Jaime et al. (2018) Meat intake in relation to semen quality and reproductive hormone levels among young men in Spain. Br J Nutr :1-10
Han, Liyuan; Duan, Donghui; Zhang, Shuang et al. (2018) Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene-weight interaction analysis. Diabetes Obes Metab 20:2733-2739
Jager, Mike; Lee, Mi-Jeong; Li, Chendi et al. (2018) Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PLoS One 13:e0197777
Cardamone, Maria Dafne; Tanasa, Bogdan; Cederquist, Carly T et al. (2018) Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell 69:757-772.e7
Martin Carli, Jayne F; LeDuc, Charles A; Zhang, Yiying et al. (2018) FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications. J Lipid Res 59:1446-1460
Buendia, Justin R; Li, Yanping; Hu, Frank B et al. (2018) Regular Yogurt Intake and Risk of Cardiovascular Disease Among Hypertensive Adults. Am J Hypertens 31:557-565

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