The Animals Models Core represents an expanded version of the former Toxicology Core. Previous work of the Core focused on animal studies to assess toxicity of vectors in support of clinical trials and basic and toxicologic research in nonhuman primates. We found that the majority of the activities of this Core were directed at addressing basic research questions. We therefore have broadened the scope of the core to support the preclinical evaluation of molecular therapies in a variety of animal models and have changed the name of the core to reflect its new mission. The foundation of the Animal Models Core is the Animal Services Unit (ASU)which provides comprehensive support in a number of animal models with a focus on mice, nonhuman primates and swine. The ASU operates a mouse facility with approximately 4000 cages and a nonhuman primate facility whose census is 50 to 60 rhesus macaques. The ASU staff provides technical, husbandry, facilities, clinical and enrichment support. The Nonhuman Primate Research group works directly with faculty to design, conduct and perform experiments in nonhuman primates. An additional aspect of the Animal Models Core is the management of a diabetic swine model in support of molecular therapy strategies for diabetes. This application requests resources to support technical services for rodent and swine experiments as well as partial support for pilot experiments in nonhuman primates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK047757-11
Application #
6775155
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2003-09-30
Budget End
2004-08-31
Support Year
11
Fiscal Year
2003
Total Cost
$309,075
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Svidritskiy, Egor; Korostelev, Andrei A (2018) Conformational Control of Translation Termination on the 70S Ribosome. Structure 26:821-828.e3
Svidritskiy, Egor; Korostelev, Andrei A (2018) Mechanism of Inhibition of Translation Termination by Blasticidin S. J Mol Biol 430:591-593
Gurda, Brittney L; De Guilhem De Lataillade, Adrien; Bell, Peter et al. (2016) Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. Mol Ther 24:206-216
Svidritskiy, Egor; Madireddy, Rohini; Korostelev, Andrei A (2016) Structural Basis for Translation Termination on a Pseudouridylated Stop Codon. J Mol Biol 428:2228-36
Greig, Jenny A; Calcedo, Roberto; Grant, Rebecca L et al. (2016) Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques. Vaccine 34:6323-6329
McClain, Lauren E; Davey, Marcus G; Zoltick, Phillip W et al. (2016) Vector serotype screening for use in ovine perinatal lung gene therapy. J Pediatr Surg 51:879-84
Calcedo, Roberto; Wilson, James M (2016) AAV Natural Infection Induces Broad Cross-Neutralizing Antibody Responses to Multiple AAV Serotypes in Chimpanzees. Hum Gene Ther Clin Dev 27:79-82
Svidritskiy, Egor; Korostelev, Andrei A (2015) Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch. Structure 23:2155-61
Wang, Lili; Bell, Peter; Somanathan, Suryanarayan et al. (2015) Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids. Mol Ther 23:1877-87
Calcedo, Roberto; Franco, Judith; Qin, Qiuyue et al. (2015) Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May Confound In Vivo Gene Therapy Studies. Hum Gene Ther Methods 26:103-5

Showing the most recent 10 out of 231 publications