Advances in perinatal care have allowed for the survival of an increasingly larger population of neonates weighing less than 1000 g, referred to as extremely-low-birthweight (ELBW) infants. Because of limited supplies of endogenous energy reserves, the ELBW infant is extremely vulnerable to inadequate nutritional intake. The optimal strategy for supplying nutrition to these infants is poorly defined because of limited information on their substrate metabolism. Using common parenteral feeding regimens, we propose to study protein kinetics and the effects of the quality of infused energy on protein metabolism in the ELBW infant in the first 48 hours of life using stable isotope methodology combined with indirect calorimetry. Stable isotopic tracers of leucine, glucose and glycerol will be infused simultaneously to determine protein synthesis and oxidation, glucose production and utilization, and the rate of lipolysis. As part of this work, validation of a neonatal indirect calorimeter designed specifically for use in premature ventilated and non-ventilated infants will be completed. A neonatal activity monitor is also being developed to use as calorimetry for further refinement of metabolic data collection.

Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Lee, Dustin M; Battson, Micah L; Jarrell, Dillon K et al. (2018) SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice. Cardiovasc Diabetol 17:62
Alexeev, Erica E; Lanis, Jordi M; Kao, Daniel J et al. (2018) Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol 188:1183-1194
Beli, Eleni; Yan, Yuanqing; Moldovan, Leni et al. (2018) Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice. Diabetes 67:1867-1879
Mintz, Michael; Khair, Shanawaj; Grewal, Suman et al. (2018) Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis. PLoS One 13:e0190997
Keller, A C; Knaub, L A; Scalzo, R L et al. (2018) Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats. Oxid Med Cell Longev 2018:7363485
Creasy, Seth A; Rynders, Corey A; Bergouignan, Audrey et al. (2018) Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring) 26:696-702
Hildreth, Kerry L; Ozemek, Cemal; Kohrt, Wendy M et al. (2018) Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. Menopause 25:1011-1019
Beune, Irene M; Bloomfield, Frank H; Ganzevoort, Wessel et al. (2018) Consensus Based Definition of Growth Restriction in the Newborn. J Pediatr 196:71-76.e1
Rynders, Corey A; Schmidt, Stacy L; Bergouignan, Audrey et al. (2018) Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiol Rep 6:
Jensen, Thomas; Abdelmalek, Manal F; Sullivan, Shelby et al. (2018) Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol 68:1063-1075

Showing the most recent 10 out of 756 publications