application) This is an application for a 5-year renewal for the Colorado Clinical Nutrition Research Unit (CNRU). The Colorado CNRU was originally funded in January 1995 to serve 41 investigators with 5 million dollars in funding for nutrition-related research. Now, if our fourth year of operation, we serve 56 investigators with approximately 10 million dollars in nutrition-related funding. The broad goal of the Colorado CNRU is to enhance the nutrition-related research of our research base and to help promising young scientists with an interest in nutrition develop into independent investigators. The theme of the Colorado CNRU, nutrient utilization, captures the broad interests of a majority of our research base members. We have identified 4 research focus areas within that broad theme: obesity and diabetes; developmental aspects of nutrient utilization; micronutrient utilization and function, and community nutrition. The research supported by the CNRU includes a continuum from the patient or healthy subject to the subcellular and molecular levels. We propose an Administrative Core and 3 scientific core laboratories: Energy Balance, Metabolic, and Mass Spectrometry. The use of core laboratories, the number of CNRU supported publications and the federal funding for nutrition research has grown steadily over our first 4 years of operation. The CNRU Director, Dr. James O. Hill and the Associate Director, Dr. Robert H. Eckel are supported by a strong Executive Committee. The Colorado CNRU is located with an exciting Center for Human Nutrition at the University of Colorado Health Sciences Center, but faculty from Colorado State University participate in the CNRU through an existing CU-CSU consortium. The Center for Human Nutrition has strong programs for nutrition education, research training, clinical nutrition services and community outreach. The existence of a CNRU in Colorado has energized an already strong group of nutrition investigators and has led to many exciting new collaborations and interactions. Through the CNRU, our nutrition investigators have gained recognition both nationally and within our universities. We look forward to continuing to enhance nutrition research within Colorado over the next 5 years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-08
Application #
6489683
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Program Officer
Hubbard, Van S
Project Start
1995-03-15
Project End
2004-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
8
Fiscal Year
2002
Total Cost
$970,315
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Daniels, Stephen; Pratt, Mick; Zhou, Yan et al. (2018) Effect of steady-state methadone on high fructose corn syrup consumption in rats. J Psychopharmacol 32:215-222
Chassen, Stephanie Skuby; Ferchaud-Roucher, Veronique; Gupta, Madhulika B et al. (2018) Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction. Clin Sci (Lond) 132:595-607
Friedman, Jacob E (2018) Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed? Diabetes 67:2137-2151
Thompson, Darcy A; Federspiel, Deborah A (2018) The Familias Saludables partnership: Engaging the Latino community to address early childhood obesity. J Comp Eff Res 7:85-88
Levy, AnneMarie; Daniels, Stephen; Hudson, Roger et al. (2018) Bupropion and naltrexone combination alters high fructose corn syrup self-administration and gene expression in rats. Neuropharmacology 135:547-554
Brown, Laura G; Hoover, Edward Rickamer; Faw, Brenda V et al. (2018) Food Safety Practices Linked with Proper Refrigerator Temperatures in Retail Delis. Foodborne Pathog Dis 15:300-307
Erlandson, Kristine M; MaWhinney, Samantha; Wilson, Melissa et al. (2018) Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection. AIDS 32:2317-2326
Rodriguez-Iturbe, Bernardo; Lanaspa, Miguel A; Johnson, Richard J (2018) The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. Br J Pharmacol :
Roncal-Jimenez, Carlos A; Sato, Yuka; Milagres, Tamara et al. (2018) Experimental heat stress nephropathy and liver injury are improved by allopurinol. Am J Physiol Renal Physiol 315:F726-F733
Battson, Micah L; Lee, Dustin M; Jarrell, Dillon K et al. (2018) Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction. Am J Physiol Endocrinol Metab 314:E468-E477

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