Abstract

The mission of the core is to provide analytical services and to develop new assays and technology to support CNRU investigators to develop an understanding of nutrient absorption, metabolism, and turnover. The Mass Spectrometry Core furnishes instruments and technologies that would not normally be available to most independent investigators and is, in fact, essential to the success of these investigators. The core is also developing diagnostic tools to predict disease and to monitor progress of disease and treatment. In addition, we provide comprehensive instruction for interested CNRU investigators in order to increase their proficiency in our highly complex technologies and instrumentation. The range of instrumentation available to CNRU investigators through the Core has significantly expanded during the last year and now includes GC-MS, isotope ratio MS, LC-MS, LC-MS/MS, LCMS/iontrap (with all components required for proteomics research), time-of-flight mass spectrometry, two-dimensional gel electrophoresis equipment and software, preparative HPLC with MS-guided automatic autosampler, 2 NMR spectrometers for biochemical profiling of cell and tissue metabolism (metabolomics) and animal MRI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK048520-11
Application #
7006531
Study Section
Special Emphasis Panel (ZDK1-GRB-1 (M2))
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2005-07-01
Budget End
2006-07-31
Support Year
11
Fiscal Year
2005
Total Cost
$192,500
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Mintz, Michael; Khair, Shanawaj; Grewal, Suman et al. (2018) Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis. PLoS One 13:e0190997
Lee, Dustin M; Battson, Micah L; Jarrell, Dillon K et al. (2018) SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice. Cardiovasc Diabetol 17:62
Alexeev, Erica E; Lanis, Jordi M; Kao, Daniel J et al. (2018) Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol 188:1183-1194
Beli, Eleni; Yan, Yuanqing; Moldovan, Leni et al. (2018) Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice. Diabetes 67:1867-1879
Beune, Irene M; Bloomfield, Frank H; Ganzevoort, Wessel et al. (2018) Consensus Based Definition of Growth Restriction in the Newborn. J Pediatr 196:71-76.e1
Keller, A C; Knaub, L A; Scalzo, R L et al. (2018) Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats. Oxid Med Cell Longev 2018:7363485
Creasy, Seth A; Rynders, Corey A; Bergouignan, Audrey et al. (2018) Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring) 26:696-702
Hildreth, Kerry L; Ozemek, Cemal; Kohrt, Wendy M et al. (2018) Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. Menopause 25:1011-1019
Bergman, Bryan C; Perreault, Leigh; Strauss, Allison et al. (2018) Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab 314:E152-E164
Rynders, Corey A; Schmidt, Stacy L; Bergouignan, Audrey et al. (2018) Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiol Rep 6:

Showing the most recent 10 out of 756 publications