The purpose of the moue core is to provide specialized mice to the investigators of this Center. The mouse core will provide 1) SCID/NOD mice for human-mouse xenografts; and 2) mouse strains used for specialized applications of stem cell and myeloid cell biology. The core utilizes equipment and expertise already in place within the Herman B Wells Center for Pediatric Research, including rodent rooms, a cesium irradiator, and specialized HEPA-filtered air mouse cage racks which house the SCID/NOD mice. All strains of mice are already used within the institution on a timely basis. The anticipated use of these colonies is projected to increase over the next five years. The core will maintain adequate numbers of breeding mice in each respective colony to provide investigators experimental mice in a timely fashion. The SCID/NOD facility is maintained with entry conditions. The mouse core will provide both housing and experimental manipulation services to the investigators to minimize the risk of colony contamination, and to facilitate experimental. All animals will be house in the Laboratory Animal Resource Center at Indiana University Medical Center, an AAALAC-approved facility.

Project Start
2000-09-01
Project End
2001-08-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2000
Total Cost
$120,834
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A et al. (2018) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell 172:191-204.e10
Xu, Linlin; Mohammad, Khalid S; Wu, Hao et al. (2016) Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma. Cancer Res 76:6901-6910
Prasain, Nutan; Lee, Man Ryul; Vemula, Sasidhar et al. (2014) Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells. Nat Biotechnol 32:1151-1157
Waning, David L; Li, Binghui; Jia, Nan et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112:320-9
Cai, Shanbao; Hartwell, Jennifer R; Cooper, Ryan J et al. (2006) In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells. Mol Ther 13:1016-26
Li, Xiaxin; Le Beau, Michelle M; Ciccone, Samantha et al. (2005) Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy. Blood 105:3465-71
Srour, Edward F; Tong, Xia; Sung, Ki Woong et al. (2005) Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34+CD38-/lo cells in G0. Blood 105:3109-16
Rinne, M L; He, Y; Pachkowski, B F et al. (2005) N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts. Nucleic Acids Res 33:2859-67
Tell, Gianluca; Damante, Giuseppe; Caldwell, David et al. (2005) The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 7:367-84
Bijangi-Vishehsaraei, Khadijeh; Saadatzadeh, M Reza; Werne, Adam et al. (2005) Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1. Blood 106:4124-30

Showing the most recent 10 out of 42 publications