Abstract

The Cell Culture Core has supported and will continue to support the Center in several ways, all with the specific goal of fostering digestive disease research in the Center. Through enhancing the quality of cell culture techniques used by Center investigators, the Cell Culture Core will be an important vehicle for collaborative digestive disease research due to availability of centralized services and reagents. The purpose of the Core are the following: to provide and maintain primary and organotropic cell cultures; to provide and maintain a repository for established malignant cell lines and adenoviral vectors, and to train Center investigators and their laboratory personnel in cell culture techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK050306-06
Application #
6646745
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2002-07-15
Project End
2007-06-30
Budget Start
Budget End
Support Year
6
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kasagi, Yuta; Chandramouleeswaran, Prasanna M; Whelan, Kelly A et al. (2018) The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol 5:333-352
Chatterji, Priya; Hamilton, Kathryn E; Liang, Shun et al. (2018) The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Genes Dev 32:1020-1034
Klingberg, Franco; Chau, Grace; Walraven, Marielle et al. (2018) The fibronectin ED-A domain enhances recruitment of latent TGF-?-binding protein-1 to the fibroblast matrix. J Cell Sci 131:
Ban, Ehsan; Franklin, J Matthew; Nam, Sungmin et al. (2018) Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J 114:450-461
Charrier, Elisabeth E; Pogoda, Katarzyna; Wells, Rebecca G et al. (2018) Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nat Commun 9:449
Yousefi, Maryam; Nakauka-Ddamba, Angela; Berry, Corbett T et al. (2018) Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells. Stem Cell Reports 10:703-711
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David et al. (2018) FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155:1741-1752.e5
Reichert, Maximilian; Bakir, Basil; Moreira, Leticia et al. (2018) Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev Cell 45:696-711.e8
Benias, Petros C; Wells, Rebecca G; Sackey-Aboagye, Bridget et al. (2018) Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Sci Rep 8:4947
Mizuno, Rei; Chatterji, Priya; Andres, Sarah et al. (2018) Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions. Mol Cancer Res 16:403-416

Showing the most recent 10 out of 700 publications