Abstract

(Comparative Pathology Core?Core 4) The goal of the Comparative Pathology Core is to provide professional services and expertise to Center Investigators of the Cystic Fibrosis Research and Translation Core Center. To facilitate these goals the Pathology Core offers 1) technical expertise and support for histotechnology techniques from tissue processing to specialized staining (histochemical and immunohistochemical) and 2) ACVP-boarded veterinary pathologist expertise and support for morphologic, quantitative and semi-quantitative evaluation of tissues from CF pig, CF mouse and CF ferret studies. The Comparative Pathology Core will provide services to Center Investigators in a timely and efficient manner for optimal assessment of tissues. The goals of the Comparative Pathology Core are to: 1. Provide histotechnology services to the Center Investigators through CPL resources and experienced staff. 2. Assist with professional necropsy services for Center Investigators. 3. Provide veterinary pathologists services to the Center Investigators. 4. Serve as a conduit for dissemination of histologic specimens from CF pig and ferret models to researchers outside the University of Iowa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK054759-21
Application #
9983933
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1998-09-30
Project End
2025-03-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
21
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Aaron, Carrie P; Schwartz, Joseph E; Hoffman, Eric A et al. (2018) A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study. Chest 154:41-50
Meyerholz, David K; Tintle, Nathan L; Beck, Amanda P (2018) Common Pitfalls in Analysis of Tissue Scores. Vet Pathol :300985818794250
Swatek, Anthony M; Lynch, Thomas J; Crooke, Adrianne K et al. (2018) Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. Am J Respir Crit Care Med 197:1045-1057
Meyerholz, David K; Beck, Amanda P (2018) Principles and approaches for reproducible scoring of tissue stains in research. Lab Invest 98:844-855
Sodhi, Chhinder P; Wohlford-Lenane, Christine; Yamaguchi, Yukihiro et al. (2018) Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. Am J Physiol Lung Cell Mol Physiol 314:L17-L31
Subramaniam, K; Clark, A R; Hoffman, E A et al. (2018) Metrics of lung tissue heterogeneity depend on BMI but not age. J Appl Physiol (1985) 125:328-339
Furqan, Muhammad; Tien, Yu-Yu; Schroeder, Mary C et al. (2018) Lobar versus sub-lobar surgery for pulmonary typical carcinoid, a population-based analysis. J Thorac Dis 10:5850-5859
Rosman, Colin W K; Romero Pastrana, Francisco; Buist, Girbe et al. (2018) Ex Vivo Tracer Efficacy in Optical Imaging of Staphylococcus Aureus Nuclease Activity. Sci Rep 8:1305
Bridges, Cory S; Miller, Pamela S; Lidbury, Jonathan A et al. (2018) Validation of a radioimmunoassay of serum trypsin-like immunoreactivity in ferrets. J Vet Diagn Invest 30:517-522
Hammond, E; Chan, K S; Ames, J C et al. (2018) Impact of advanced detector technology and iterative reconstruction on low-dose quantitative assessment of lung computed tomography density in a biological lung model. Med Phys :

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