This revised application is submitted in response to RFA DK-99-017, Silvio O. Conte Digestive Disease Research Core Center requesting establishment of a Texas Gulf Coast Digestive Diseases Center (called DDC for simplicity). This Center will serve basic and clinical scientists at institutions within the Texas Medical Center (Baylor College of Galveston. Our qualifying Funded Research Base is $9,031, 281 million (direct costs) and includes 34 separate awards from NIDDK totaling in excess of $4,647,452 million (direct costs). Reflecting the goals of these projects, we propose to establish a Center for Gastrointestinal Development, Infection and Injury. This application has developed from a core group of investigators who began interacting formally in 1996 to explore the need and interest in establishing a Center. These interactions were initiated by a Pediatric Training Program in Gastroenterology at Baylor whose faculty now represent key investigators in our proposed Center. Institutional resource commitments in space, funds and personnel support this effort. New positions in both pediatric and adult Gastroenterology for multi- disciplinary, independent faculty to establish new research programs have also been made available. We propose to utilize the Center to facilitate on-going Digestive Diseases research, promote translational research between basic and clinical areas, develop new projects, nurture new investigators, and provide GI educational activities. Support is requested for Basic Science Cores (Morphology, Cell and Molecular Biology, Gastrointestinal Immunology, Integrative Biology) and one Clinical Core (Study Design and Specimen Collection). Pilot/Feasibility and Enrichment Programs to support innovative Programs to support innovative ideas and new investigators in Digestive Disease research and foster collaboration are a key part of our Center. The Center draws together a multi-disciplinary group of investigators, including basic scientists with proven track records of success, and well- coordinated clinical programs dealing with pediatric and adult GI patients. Center leaders are senior scientists-administrators experienced in directing interactive, multi-disciplinary programs. A large, multi-ethnic population of infants and adults with Digestive Diseases emphasizes the need and the opportunities for this Center. Various groups involved in GI research and education in the Gulf Coast Area of Texas have indicated a willingness to work with the Center. The elements are in place for a NIDDK-funded DDRCC to promote coordinated Digestive Disease activities in the area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056338-05
Application #
6843814
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (M1))
Program Officer
Podskalny, Judith M,
Project Start
2001-04-15
Project End
2008-02-28
Budget Start
2005-03-01
Budget End
2008-02-28
Support Year
5
Fiscal Year
2005
Total Cost
$900,000
Indirect Cost
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Graham, David Y; Dore, Maria Pina; Lu, Hong (2018) Understanding treatment guidelines with bismuth and non-bismuth quadruple Helicobacter pylori eradication therapies. Expert Rev Anti Infect Ther 16:679-687
Jarrett, Kelsey E; Lee, Ciaran; De Giorgi, Marco et al. (2018) Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol 38:1997-2006
Call, Lee; Stoll, Barbara; Oosterloo, Berthe et al. (2018) Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC. Microbiome 6:111
Yuan, Xiaoyi; Lee, Jae W; Bowser, Jessica L et al. (2018) Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesth Analg 126:308-321
Donaldson, G P; Ladinsky, M S; Yu, K B et al. (2018) Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360:795-800
White, Donna L; Hoogeveen, Ron C; Chen, Liang et al. (2018) A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women. Cancer Med 7:2180-2191
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:
Blutt, Sarah E; Crawford, Sue E; Ramani, Sasirekha et al. (2018) Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol 5:241-251
Yu, Wangie; Chen, Yunyun; Dubrulle, Julien et al. (2018) Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism. Sci Rep 8:4306
Mindikoglu, Ayse L; Pappas, Stephen C (2018) Predictors of Response to Terlipressin in Hepatorenal Syndrome. Clin Gastroenterol Hepatol 16:1174

Showing the most recent 10 out of 1121 publications