The establishment and Endocrinology Research Center (DERC) at the Barbara Davis Center for Childhood Diabetes (BDC) at the University of Colorado Health Sciences (UCHSC) brings together the collective expertise of basic and clinical scientists from different faculty and research backgrounds to enhance productivity and the quality of diabetes and endocrinology research in the university. Interdisciplinary cooperation, communication and collaboration between researchers will be promoted by implementation of programs of training and academic enrichment, provision of Core facilities and a Pilot and Feasibility project program. The latter is aimed at fostering innovative ideas of young faculty and established researchers who wish to direct their research efforts to diabetes. All core facilities will be located at the BDC and managed by BDC members. Individuals with particular expertise at the UCHSC and National Jewish Medical Research Center have been included as investigators and advisors as a deliberate strategy aimed at providing further added value and cost effectiveness to the program. The Core facilities are structured around existing expertise services or large instrumentation which, by addition of staff and resources, will provide a productive and cost-effective resource to the maximum number of investigators. Five Cores are proposed: Administration (J. Hutton &G. Eisenbarth, directors); Cytometry (D. Bellgrau, directors); Animal Resources (R. Gill & D. Wegmann, directors); Cell and Molecular Resources (J. Hutton & L. Sussel, directors) and Clinical Investigation/Informatics (M. Rewers & P. Chase, directors). They will be accommodated in 2,147 square feet of approved reassigned space in the present BDC building on 9th and Colorado Blvd on the UCHSC campus. No items of large equipment are needed by the DERC Cores as these have been acquired. Two novel features of the proposed DERC are a """"""""Molecular Bed and Breakfast"""""""" laboratory that will accommodate investigators for 2-4 weeks for in-house, hands-on training in either basic or advanced molecular biology techniques for 2-4 weeks for in-house, hands-on training in either basic or advanced molecular biology techniques, and a Translational Research Unit which will guide investigators through the labyrinth of setting up a clinical study. Dr. Hutton, PhD will be the Director of the Center and Dr. Eisenbarth, MD, PhD will be his deputy. An External Advisory Board comprised of four distinguished investigators in the field of diabetes will be appointed to provide oversight, assist in the selection of Pilot and Feasibility Projects and conduct an annual review of the DERC. The activities of the DERC will be broadly disseminated to the NIDDK, UCHSC, local chapter of the Juvenile Diabetes Foundation International or the American Diabetes Association by direct communication and publicity of the BDC webpage.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
1P30DK057516-01
Application #
6081800
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J1))
Program Officer
Abraham, Kristin M
Project Start
2000-06-01
Project End
2005-03-31
Budget Start
2000-06-01
Budget End
2001-03-31
Support Year
1
Fiscal Year
2000
Total Cost
$1,000,000
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Li, Chao; D'Agostino Jr, Ralph B; Dabelea, Dana et al. (2018) Longitudinal association between eating frequency and hemoglobin A1c and serum lipids in diabetes in the SEARCH for Diabetes in Youth study. Pediatr Diabetes :
Kahkoska, Anna R; Isom, Scott; Divers, Jasmin et al. (2018) The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes. J Diabetes Complications 32:1160-1168
Millstein, Richard J; Pyle, Laura L; Bergman, Bryan C et al. (2018) Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications 32:418-423
Steck, Andrea K; Dong, Fran; Frohnert, Brigitte I et al. (2018) Predicting progression to diabetes in islet autoantibody positive children. J Autoimmun 90:59-63
Costacou, Tina; Crandell, Jamie; Kahkoska, Anna R et al. (2018) Dietary Patterns Over Time and Microalbuminuria in Youth and Young Adults With Type 1 Diabetes: The SEARCH Nutrition Ancillary Study. Diabetes Care 41:1615-1622
Jaiswal, Mamta; Divers, Jasmin; Urbina, Elaine M et al. (2018) Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatr Diabetes 19:680-689
Liu, Chih-Wei; Bramer, Lisa; Webb-Robertson, Bobbie-Jo et al. (2018) Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression. J Proteomics 172:100-110
Reynolds, Kristi; Saydah, Sharon H; Isom, Scott et al. (2018) Mortality in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study. J Diabetes Complications 32:545-549
Plenter, Robert J; Grazia, Todd J; Coulombe, Marilyne G et al. (2018) Anti-LFA-1 induces CD8 T-cell dependent allograft tolerance and augments suppressor phenotype CD8 cells. Cell Immunol 332:101-110
Liese, Angela D; Ma, Xiaonan; Ma, Xiaoguang et al. (2018) Dietary quality and markers of inflammation: No association in youth with type 1 diabetes. J Diabetes Complications 32:179-184

Showing the most recent 10 out of 480 publications