The Columbia University Diabetes Research Center was established in May 2003. As the focus of diabetes research at the largest academic medical center in the largest U.S. metropolitan area, the Columbia DRC promotes interactions among members of an outstanding research base, integrating basic and translational diabetes research with existing institutional centers of excellence in obesity, atherosclerosis, neurobiology, and cardiovascular biology. The DRC fosters translation of basic research advances, clinical training, epidemiology, and?through its partnership with the Naomi Berrie Diabetes Center?encourages diabetes- related philanthropy. The Biomedical Research Base is comprised of 61 NIH-, ADA- and/or JDRF-funded investigators at Columbia, and 2 associate members at sister institutions in New York City. The DRC supports four technical Core facilities: Translational Biomarker Analytical Core (B); Advanced Tissue Pathology Imaging Core (E); Mouse Metabolic Function & Phenotyping Core (F); Cytometry & Cell Sorting Core (G); and an Administrative Core that coordinates the activities of these service Cores. Additionally, the DRC makes available funding for young investigators through a Pilot/Feasibility grant program (PF), and provides established scientists in other research areas at Columbia University - and in neighboring institutions - with the opportunity and support to enter the diabetes field through this program. The DRC supports Program Enrichment activities designed to increase the awareness of diabetes research in the scientific/academic community at Columbia University; it also promotes interactions with academic institutions in the greater New York area. The Administrative Core provides overall logistical support and programmatic leadership, financial oversight and integration of research efforts, shared core facilities, and PF program administration. During the past funding cycle, the DRC has endeavored to advance NIDDK?s mission in diabetes by: (i) providing state-of-the-art core facilities to enhance the research programs of DRC members and contributing to the development of innovative methods for diabetes research and care (ii) raising awareness of and interest in advanced clinical and basic diabetes research at Columbia University and in New York City; (iii) enhancing training and other diabetes-related educational opportunities for students, fellows, academic and community-based physicians, including a highly subscribed summer NIDDK-sponsored summer research program for medical students from around the United States; (iv) attracting new investigators to diabetes research;; (v) fostering a collegial academic environment to facilitate information exchange within the institution and with other DRCs; (vi) providing impetus and resources to translate basic science discoveries into clinical care and community initiatives to improve the health of people with diabetes; and (vii) leveraging NIDDK resources with local and national philanthropic and diabetes advocacy organizations to integrate and expand PF grants, as well as training and educational programs.

Public Health Relevance

The Columbia University Diabetes Research Center continues to facilitate interactions among investigators from different academic backgrounds, providing material and intellectual support for initiatives that broaden our understanding of the causes of diabetes, and improve treatment outcomes; and to underwrite the operation of technical facilities for data acquisition and analysis, training opportunities for young investigators and students, and seeding funds for potentially transformative research projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK063608-19
Application #
10104475
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Silva, Corinne M
Project Start
2002-09-01
Project End
2023-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
19
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Savage, Thomas M; Shonts, Brittany A; Obradovic, Aleksandar et al. (2018) Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight 3:
Molusky, Matthew M; Hsieh, Joanne; Lee, Samuel X et al. (2018) Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences. Arterioscler Thromb Vasc Biol 38:1493-1503
Carpenter, D J; Granot, T; Matsuoka, N et al. (2018) Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation. Am J Transplant 18:74-88
Langlet, Fanny; Tarbier, Marcel; Haeusler, Rebecca A et al. (2018) microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function. Mol Metab 17:49-60
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Carli, Jayne F Martin; LeDuc, Charles A; Zhang, Yiying et al. (2018) The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function. FASEB J 32:3946-3956
Postigo-Fernandez, Jorge; Creusot, RĂ©mi J (2018) A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes. J Autoimmun :
Proto, Jonathan D; Doran, Amanda C; Subramanian, Manikandan et al. (2018) Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 128:2370-2375
Martin Carli, Jayne F; LeDuc, Charles A; Zhang, Yiying et al. (2018) FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications. J Lipid Res 59:1446-1460
Arnes, Luis; Liu, Zhaoqi; Wang, Jiguang et al. (2018) Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut :

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