Abstract

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-04
Application #
7669115
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$408,538
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Obanda, Diana; Page, Ryan; Guice, Justin et al. (2018) CD Obesity-Prone Rats, but not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight or Fat Accretion. Obesity (Silver Spring) 26:570-577
Yan, Hao; Carmichael, Owen; Paul, Debashis et al. (2018) Estimating fiber orientation distribution from diffusion MRI with spherical needlets. Med Image Anal 46:57-72
Trepanowski, John F; Kroeger, Cynthia M; Barnosky, Adrienne et al. (2018) Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clin Nutr 37:1871-1878
Wanders, Desiree; Forney, Laura A; Stone, Kirsten P et al. (2018) The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats. Obesity (Silver Spring) 26:740-746
Carmichael, Owen; Schwarz, Adam J; Chatham, Christopher H et al. (2018) The role of fMRI in drug development. Drug Discov Today 23:333-348
Staiano, Amanda E; Webster, Elizabeth Kipling; Allen, Andrew T et al. (2018) Screen-Time Policies and Practices in Early Care and Education Centers in Relationship to Child Physical Activity. Child Obes 14:341-348
Poret, J M; Souza-Smith, F; Marcell, S J et al. (2018) High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond) 42:535-541
François, Marie; Qualls-Creekmore, Emily; Berthoud, Hans-Rudolf et al. (2018) Genetics-based manipulation of adipose tissue sympathetic innervation. Physiol Behav 190:21-27
Toledo, Frederico G S; Johannsen, Darcy L; Covington, Jeffrey D et al. (2018) Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals. Diabetologia 61:466-475
Gautier, Jean-François; Fetita, Lila Sabrina; Riveline, Jean-Pierre et al. (2018) Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion. J Endocr Soc 2:391-397

Showing the most recent 10 out of 759 publications