Abstract

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-05
Application #
7918063
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$378,569
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Bruce-Keller, Annadora J; Salbaum, J Michael; Berthoud, Hans-Rudolf (2018) Harnessing Gut Microbes for Mental Health: Getting From Here to There. Biol Psychiatry 83:214-223
Yu, Sangho; Münzberg, Heike (2018) Testing Effects of Chronic Chemogenetic Neuronal Stimulation on Energy Balance by Indirect Calorimetry. Bio Protoc 8:
Elbers, Jean P; Brown, Mary B; Taylor, Sabrina S (2018) Identifying genome-wide immune gene variation underlying infectious disease in wildlife populations - a next generation sequencing approach in the gopher tortoise. BMC Genomics 19:64
Kaviani, Sepideh; Schoeller, Dale A; Ravussin, Eric et al. (2018) Determining the Accuracy and Reliability of Indirect Calorimeters Utilizing the Methanol Combustion Technique. Nutr Clin Pract 33:206-216
Peterson, Courtney M; Beyl, Robbie A; Marlatt, Kara L et al. (2018) Effect of 12 wk of resistant starch supplementation on cardiometabolic risk factors in adults with prediabetes: a randomized controlled trial. Am J Clin Nutr 108:492-501
Graf, Brittany L; Zhang, Li; Corradini, Maria G et al. (2018) Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome. J Funct Foods 45:268-276
Clark, Richard V; Walker, Ann C; Miller, Ram R et al. (2018) Creatine ( methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA. J Appl Physiol (1985) 124:1-9
Most, Jasper; Gilmore, L Anne; Altazan, Abby D et al. (2018) Propensity for adverse pregnancy outcomes in African-American women may be explained by low energy expenditure in early pregnancy. Am J Clin Nutr 107:957-964
White, Ursula A; Fitch, Mark D; Beyl, Robbie A et al. (2018) Racial differences in in vivo adipose lipid kinetics in humans. J Lipid Res 59:1738-1744
Stephens, Jacqueline M; Bailey, Jennifer L; Hang, Hardy et al. (2018) Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte-Specific Oncostatin Receptor Knockout Mice. Obesity (Silver Spring) 26:1439-1447

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