Abstract

This research and research training program emphasizes a variety of laboratory studies and epidemiologic approaches to the study of the effects of environmental and occupational factors on the health of man. Specific examples include the following: biology of alveolar macrophages as a pulmonary defense mechanism; effects of breathing pattern and lung volume on the distribution of inhaled particles; development and exploitation of differentiated mammalian cell culture systems to detect, examine the mechanisms of action, and develop means for prevention or reversal of certain environmental chemical toxic agents; development of new chemical and immunologic assay methods for certain classes of environmental chemicals; development and use of affinity probes to identify the sites and molecular mechanisms of action of specific toxic agents; malignant transformation in vitro; cancer morbidity and mortality among rubber workers; pulmonary function changes in granite dust exposures, toluene di-isocyanate exposures, and other occupational exposures; the uses of proportional mortality analysis in identifying suspected occupational exposures; a prospective study of children and adults exposed to specific indoor and outdoor air pollutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000002-25
Application #
3102212
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-12-01
Project End
1987-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
25
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Messerlian, Carmen; Williams, Paige L; Ford, Jennifer B et al. (2018) The Environment and Reproductive Health (EARTH) Study: A Prospective Preconception Cohort. Hum Reprod Open 2018:
Li, Wenyuan; Nyhan, Marguerite M; Wilker, Elissa H et al. (2018) Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study. Environ Int 121:1210-1216
Lepeule, Johanna; Litonjua, Augusto A; Gasparrini, Antonio et al. (2018) Lung function association with outdoor temperature and relative humidity and its interaction with air pollution in the elderly. Environ Res 165:110-117
Draz, Mohamed Shehata; Moazeni, Maryam; Venkataramani, Manasa et al. (2018) Hybrid Paper-Plastic Microchip for Flexible and High-Performance Point-of-Care Diagnostics. Adv Funct Mater 28:
Gaskins, Audrey J; Hart, Jaime E; Mínguez-Alarcón, Lidia et al. (2018) Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization. Environ Int 115:239-246
Specht, Aaron J; Kponee, Kale; Nkpaa, Kpobari W et al. (2018) Validation of x-ray fluorescence measurements of metals in toenail clippings against inductively coupled plasma mass spectrometry in a Nigerian population. Physiol Meas 39:085007
Nassan, Feiby L; Williams, Paige L; Gaskins, Audrey J et al. (2018) Correlation and temporal variability of urinary biomarkers of chemicals among couples: Implications for reproductive epidemiological studies. Environ Int 123:181-188
Weisskopf, Marc G; Seals, Ryan M; Webster, Thomas F (2018) Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures. Environ Health Perspect 126:047003
Hart, Jaime E; Bertrand, Kimberly A; DuPre, Natalie et al. (2018) Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses' health study II. Environ Health 17:28
Raz, Raanan; Kioumourtzoglou, Marianthi-Anna; Weisskopf, Marc G (2018) Live-Birth Bias and Observed Associations Between Air Pollution and Autism. Am J Epidemiol 187:2292-2296

Showing the most recent 10 out of 1142 publications